Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance.
Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance.
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DOI：
10.3390/nu9121348
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发表时间：
2017-12-12
期刊：
影响因子：
5.9
通讯作者：
Henagan TM
中科院分区：
文献类型：
--
作者：
McNabney SM;Henagan TM
增加膳食纤维的消耗与许多有益的效果有关，包括改善肥胖和胰岛素抵抗。这些影响可能是由于结肠中膳食纤维发酵期间短链脂肪酸（包括丙酸、乙酸和丁酸）的产生增加。事实上，单独的丁酸盐的口服和膳食补充剂已经显示出预防高脂肪饮食诱导的肥胖和胰岛素抵抗。本文综述了短链脂肪酸的来源，重点是丁酸的来源，纤维和丁酸在肠道中的代谢机制及其对结肠癌的保护作用，以及补充丁酸在外周组织中预防和逆转肥胖和胰岛素抵抗的外周效应。
Increased dietary fiber consumption has been associated with many beneficial effects, including amelioration of obesity and insulin resistance. These effects may be due to the increased production of short chain fatty acids, including propionate, acetate and butyrate, during fermentation of the dietary fiber in the colon. Indeed, oral and dietary supplementation of butyrate alone has been shown to prevent high fat-diet induced obesity and insulin resistance. This review focuses on sources of short chain fatty acids, with emphasis on sources of butyrate, mechanisms of fiber and butyrate metabolism in the gut and its protective effects on colon cancer and the peripheral effects of butyrate supplementation in peripheral tissues in the prevention and reversal of obesity and insulin resistance.
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