An Optimized Two-Herb Chinese Food as Medicine Formula Reduces Cisplatin-Induced Nephrotoxicity in the Treatment of Lung Cancer in Mice.
An Optimized Two-Herb Chinese Food as Medicine Formula Reduces Cisplatin-Induced Nephrotoxicity in the Treatment of Lung Cancer in Mice.
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DOI：
10.3389/fphar.2022.827901
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发表时间：
2022
影响因子：
5.6
通讯作者：
Hu X
中科院分区：
文献类型：
--
作者：
Shi L;Shu Y;Hu X;Akram W;Wang J;Dong S;Luo B;Zhang J;Hu S;Li X;Hu X
化疗被认为是治疗癌症最有效的方法。然而，化疗给癌症患者带来难以忍受的精神和身体副作用是很常见的，最终降低了患者战胜疾病的信心，影响了化疗的治疗效果。顺铂（DDP）是一种广泛用于治疗多种癌症的抗癌药物，它也会损害非肿瘤细胞和组织，这主要与炎症途径的激活有关。此前，我们已经在体外和体内模型中发现了一些以食物作为药物材料的合理配方，可以减少全身炎症。因此，本研究报道了一种优化的中药抗炎制剂能够在体外和体内协同 DDP 的抗肿瘤作用。更重要的是，通过将两种抗炎草药菊花×桑叶（Ramat.）Hemsl [菊科]和忍冬[忍冬科]与介质甘草（Glycyrrhiza uralensis Fisch）配制在一起。 ex DC [豆科]，是缓解DDP对肾脏损害的最佳配方。三种草药的主要化学成分的各种组合的治疗也表现出类似的降低 DDP 诱导的肾毒性的趋势；然而，与草药提取物配方相反，所有化学配方均不能恢复经DDP治疗的荷瘤小鼠的体重和食物摄入量。我们的研究结果表明，通过最大限度地减少两药配方的毒性，抑制小鼠肿瘤模型和 DDP 诱导的急性肾损伤小鼠模型的炎症，可以提高基于 DDP 的化疗的治疗指数。
Chemotherapy is considered a most effective way to treat cancer. However, it is very common that chemotherapy causes unbearable mental and physical side effects to cancer patients, which ultimately reduces the patients’ confidence of overcoming diseases and compromises the treatment of chemotherapy. Cisplatin (DDP), a widely used anticancer agent for various types of cancers, also damages nontumor cells and tissues, which are mostly related to the activation of the inflammation pathway. Previously, we have discovered a few rational formulas of food as medicine materials that reduced systemic inflammation in in vitro and in vivo models. Hence, this study reports the ability of an optimized traditional Chinese anti-inflammatory formulation capable of synergizing the antitumor effect of DDP in vitro and in vivo. More significantly, by formulation of two anti-inflammatory herbal medicine, the Chrysanthemum × morifolium (Ramat.) Hemsl [Asteraceae] and Lonicera japonica Thunb [Caprifoliaceae] with a mediator Glycyrrhiza uralensis Fisch. ex DC [Fabaceae], a best formula relieved the kidney damage imposed by DDP. Treatments of various combinations of major chemical components of the three herbs also exhibited a similar trend for lowering the DDP-induced nephrotoxicity; however, contrary to that of the formula of herbal extracts, all chemical formulas could not recover the body weight and food intake of the tumor-bearing mice treated by DDP. Our findings suggested that the therapeutic index of DDP-based chemotherapy was able to be improved by minimizing toxicities from the two-herb formula to inhibit the inflammation in mouse tumor models and DDP-induced acute kidney injury mouse models.
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影响因子：
16.2
作者：
Feng, Rui-Mei;Zong, Yi-Nan;Xu, Rui-Hua
通讯作者：
Xu, Rui-Hua
影响因子：
5.3
作者：
Alhadeff, Amber L.;Holland, Ruby A.;De Jonghe, Bart C.
通讯作者：
De Jonghe, Bart C.
甘草活性成分甘草甜素和甘草次酸能治疗类风湿关节炎吗？
影响因子：
--
作者：
Huang QC;Wang MJ;Chen XM;Yu WL;Chu YL;He XH;Huang RY
通讯作者：
Huang RY
影响因子：
19.6
作者：
Deng, JP;Kohda, Y;Star, RA
通讯作者：
Star, RA
影响因子：
5.6
作者：
Wang J;Zhou B;Hu X;Dong S;Hong M;Wang J;Chen J;Zhang J;Zhang Q;Li X;Shikov AN;Hu S;Hu X
通讯作者：
Hu X