Mechanoreceptor synapses in the brainstem shape the central representation of touch.
Mechanoreceptor synapses in the brainstem shape the central representation of touch.
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脑干中的机械感受器突触塑造了触觉的中心表征。
DOI：
10.1016/j.cell.2021.09.023
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发表时间：
2021-10-28
期刊：
影响因子：
64.5
通讯作者：
Ginty DD
中科院分区：
文献类型：
--
作者：
Lehnert BP;Santiago C;Huey EL;Emanuel AJ;Renauld S;Africawala N;Alkislar I;Zheng Y;Bai L;Koutsioumpa C;Hong JT;Magee AR;Harvey CD;Ginty DD
哺乳动物使用他们的手和脚的无毛皮肤来导航和操纵他们的环境。跨物种的身体表面的皮质地图包含不成比例的大量神经元专用于无毛皮肤感觉，部分反映了更高密度的机械感受器，支配这些皮肤区域。在这里，我们发现，不成比例的代表性无毛皮肤出现在出生后的发展在外周机械感受器和他们的中央目标之间的第一个突触在脑干。机械感受器突触经过发育完善，这取决于其终端接近无毛皮肤，这样那些支配无毛皮肤的突触连接，扩大其中央代表。在无法感知轻柔触摸的小鼠中，支配无毛皮肤的机械感受器仍然在脑干中产生更强大的突触。我们建议，皮肤区域的机械感受器支配控制其中央突触的发展，以塑造触摸在大脑中的代表性的细化。与神经支配多毛皮肤的机械感受器相比，神经支配无毛皮肤的机械感受器在脑干上行投射神经元上形成更多且更强大的突触连接。这表明皮肤类型影响大脑中的神经元如何代表身体中的神经元。
Mammals use glabrous (hairless) skin of their hands and feet to navigate and manipulate their environment. Cortical maps of the body surface across species contain disproportionately large numbers of neurons dedicated to glabrous skin sensation, in part reflecting a higher density of mechanoreceptors that innervate these skin regions. Here, we find that disproportionate representation of glabrous skin emerges over postnatal development at the first synapse between peripheral mechanoreceptors and their central targets in the brainstem. Mechanoreceptor synapses undergo developmental refinement that depends on proximity of their terminals to glabrous skin, such that those innervating glabrous skin make synaptic connections that expand their central representation. In mice incapable of sensing gentle touch, mechanoreceptors innervating glabrous skin still make more powerful synapses in the brainstem. We propose that the skin region a mechanoreceptor innervates controls refinement of its central synapses over development to shape the representation of touch in the brain. Mechanoreceptors that innervate glabrous skin form more numerous and more powerful synaptic connections onto brainstem ascending projection neurons as compared to mechanoreceptors that innervate hairy skin. This suggests that skin type affects how neurons in the brain represent neurons in the body.
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影响因子：
3.7
作者：
Badea TC;Hua ZL;Smallwood PM;Williams J;Rotolo T;Ye X;Nathans J
通讯作者：
Nathans J
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影响因子：
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Nonomura K;Woo SH;Chang RB;Gillich A;Qiu Z;Francisco AG;Ranade SS;Liberles SD;Patapoutian A
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Patapoutian A
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Litwin-Kumar A;Harris KD;Axel R;Sompolinsky H;Abbott LF
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Abbott LF
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64.8
作者：
AZZOPARDI, P;COWEY, A
通讯作者：
COWEY, A
影响因子：
25
作者：
Catania, KC
通讯作者：
Catania, KC