Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex.
Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex.
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DOI：
10.1016/j.neuroscience.2012.03.041
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发表时间：
2012-06-14
期刊：
影响因子：
3.3
通讯作者：
Kabbaj, M.
中科院分区：
文献类型：
--
作者：
Carrier, N.;Kabbaj, M.
焦虑症的发病率和流行率存在相当大的性别差异，女性比男性更焦虑，特别是在需要社会互动的情况下。在临床前研究中，社交互动测试是研究社交焦虑性别差异的有效动物模型。事实上，雌性大鼠比雄性大鼠更少参与同种互动，这是雌性大鼠更高社交焦虑的行为表现。在这项工作中，我们牵连细胞外信号调节激酶2（ERK 2）在内侧前额叶皮层（mPFC）介导的社会互动。事实上，与雄性大鼠相比，雌性大鼠的ERK 2表达较低，mPFC中ERK 2的过表达增加了它们的社会互动，达到了雄性大鼠的水平。这些数据表明，ERK2的性二态表达介导的社会焦虑样行为。
Considerable sex differences occur in the incidence and prevalence of anxiety disorders where women are more anxious than men, particularly in situations where social interaction is required. In preclinical studies, the social interaction test represents a valid animal model to study sex differences in social anxiety. Indeed, female rats engage less in conspecific interactions than their male counterparts, which are behaviors indicative of higher social anxiety in female rats. In this work, we implicated extracellular signal regulated kinase 2 (ERK2) in the medial prefrontal cortex (mPFC) in mediating social interaction. Indeed, female rats’ had lower ERK2 expression compared to male rats, and overexpression of ERK2 in the mPFC increases their social interaction to the level seen in their male counterparts. These data indicate that the sexually dimorphic expression of ERK2 mediates social anxiety-like behaviors.
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