Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms.
Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms.
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DOI：
10.1016/j.biopsych.2016.04.006
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发表时间：
2017-03-15
影响因子：
10.6
通讯作者：
Berretta, Sabina
中科院分区：
文献类型：
--
作者：
Pantazopoulos, Harry;Wiseman, Jason T.;Markota, Matej;Ehrenfeld, Lucy;Berretta, Sabina
越来越多的证据表明生长抑素（SST）在精神分裂症（SZ）和双相情感障碍（BD）中起关键作用。在杏仁核中，表达SST的神经元在焦虑的调节中发挥重要作用，通常与这些疾病共病。我们测试的假设，SST免疫反应（IR）神经元减少，在杏仁核的受试者SZ和BD。证据表明，昼夜节律SST表达的杏仁核和破坏昼夜节律和节奏高峰的焦虑BD表明，在这种疾病的SST的节奏表达中断。杏仁核部分从12 SZ，15 BD，和15个对照组进行处理SST和神经肽Y（NPY），神经肽部分共表达在SST-IR神经元的免疫细胞化学。测定IR神经元总数（Nt）。死亡时间（TOD）被用来测试与昼夜节律的关联。在BD（Nt，p= 0.003）和SZ（Nt，p=0.02）中，外侧杏仁核中的SST-IR神经元减少。在正常对照组中，SST-IR神经元的Nt根据TOD而变化。这种模式在BD中改变，其特征在于对应于当天（06：00-17：59）的TOD受试者中选择性地减少SST-IR神经元。神经肽Y阳性神经元的数量不受影响。SZ和BD杏仁核中SST-IR神经元减少，在这里解释为SST表达减少，可能会破坏这些受试者对恐惧和焦虑调节的反应。在BD中，我们的研究结果提出了这样一种可能性，即早晨的焦虑高峰取决于杏仁核中SST表达的昼夜节律调节的破坏。
Growing evidence points to a key role for somatostatin (SST) in schizophrenia (SZ) and bipolar disorder (BD). In the amygdala, neurons expressing SST play an important role in the regulation of anxiety, often comorbid in these disorders. We tested the hypothesis that SST-immunoreactive (IR) neurons are decreased in the amygdala of subjects with SZ and BD. Evidence for circadian SST expression in the amygdala and disrupted circadian rhythms and rhythmic peaks of anxiety in BD suggest a disruption of rhythmic expression of SST in this disorder. Amygdala sections from 12 SZ, 15 BD, and 15 control subjects were processed for immunocytochemistry for SST and neuropeptide Y (NPY), a neuropeptide partially co-expressed in SST-IR neurons. Total numbers (Nt) of IR neurons were measured. Time of death (TOD) was used to test associations with circadian rhythms. SST-IR neurons were decreased in the lateral amygdala nucleus in BD (Nt, p= 0.003) and SZ (Nt, p=0.02). In normal controls, Nt of SST-IR neurons varied according to TOD. This pattern was altered in BD, characterized by decreases of SST-IR neurons selectively in subjects with TOD corresponding to the day (06:00–17:59). Numbers of NPY-IR neurons were not affected. Decreased SST-IR neurons in the amygdala of SZ and BD, interpreted here as decreased SST expression, may disrupt responses to fear and anxiety regulation in these subjects. In BD, our findings raise the possibility that morning peaks of anxiety depend on a disruption of circadian regulation of SST expression in the amygdala.
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影响因子：
56.9
作者：
Dulcis, Davide;Jamshidi, Pouya;Spitzer, Nicholas C.
通讯作者：
Spitzer, Nicholas C.
影响因子：
5.6
作者：
Etain, B.;Milhiet, V.;Leboyer, M.
通讯作者：
Leboyer, M.
影响因子：
2.9
作者：
DONALDSON, JA;STEPHAN, FK
通讯作者：
STEPHAN, FK
DOI：
10.1126/science.aaa5694
发表时间：
2016-01-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Basu J;Zaremba JD;Cheung SK;Hitti FL;Zemelman BV;Losonczy A;Siegelbaum SA
通讯作者：
Siegelbaum SA
影响因子：
3.7
作者：
Al-Safadi S;Branchaud M;Rutherford S;Amir S
通讯作者：
Amir S