Application of Adipose-Tissue Derived Products for Burn Wound Healing.
Application of Adipose-Tissue Derived Products for Burn Wound Healing.
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DOI：
10.3390/ph16091302
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发表时间：
2023-09-14
期刊：
影响因子：
--
通讯作者：
Ejaz A
中科院分区：
文献类型：
--
作者：
Malekzadeh H;Tirmizi Z;Arellano JA;Egro FM;Ejaz A
烧伤是一个重要的全球健康问题，导致高发病率和死亡率。深度烧伤通常导致延迟愈合和疤痕形成，需要有效的治疗方案。再生医学，特别是使用脂肪源性干细胞（ASC）的细胞治疗，已成为改善烧伤伤口愈合和减少疤痕的一种有前途的方法。体外和临床前研究都证明了ASC和基质血管组分（SVF）在解决烧伤伤口方面的功效。已经以各种形式研究了ASC用于烧伤愈合的应用，包括在动物烧伤模型中以悬浮液或支架内递送的自体或同种异体细胞。此外，ASC衍生的非细胞组分，如条件培养基或外泌体已显示出前景。已经证明在烧伤部位注射ASC和SVF通过减少炎症和促进血管生成、上皮形成和肉芽组织形成（通过其旁分泌分泌体）来增强伤口愈合。本文综述了脂肪组织衍生物在烧伤治疗中的应用，包括ASC移植，以及利用非细胞成分的治疗效益。未来ASCs在烧伤愈合中的应用将需要解决供体变异性、安全性和有效性，以确保成功的临床应用。
Burn injuries are a significant global health concern, leading to high morbidity and mortality. Deep burn injuries often result in delayed healing and scar formation, necessitating effective treatment options. Regenerative medicine, particularly cell therapy using adipose-derived stem cells (ASCs), has emerged as a promising approach to improving burn wound healing and reducing scarring. Both in vitro and preclinical studies have demonstrated the efficacy of ASCs and the stromal vascular fraction (SVF) in addressing burn wounds. The application of ASCs for burn healing has been studied in various forms, including autologous or allogeneic cells delivered in suspension or within scaffolds in animal burn models. Additionally, ASC-derived non-cellular components, such as conditioned media or exosomes have shown promise. Injection of ASCs and SVF at burn sites have been demonstrated to enhance wound healing by reducing inflammation and promoting angiogenesis, epithelialization, and granulation tissue formation through their paracrine secretome. This review discusses the applications of adipose tissue derivatives in burn injury treatment, encompassing ASC transplantation, as well as the utilization of non-cellular components utilization for therapeutic benefits. The application of ASCs in burn healing in the future will require addressing donor variability, safety, and efficacy for successful clinical application.
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