Clinical chorioamnionitis at term: the amniotic fluid fatty acyl lipidome[S]
Clinical chorioamnionitis at term: the amniotic fluid fatty acyl lipidome[S]
复制标题
临床足月绒毛膜羊膜炎：羊水脂肪酰脂质组[S]
作者：
K. Maddipati;R. Romero;T. Chaiworapongsa;P. Chaemsaithong;Sen;Zhonghui Xu;A. Tarca;J. Kusanovic;R. Gomez;N. Docheva;K. Honn
足月临床绒毛膜炎（TCC）是世界范围内分娩和分娩单位诊断的最常见的产科疾病，与孕产妇和新生儿发病率和死亡率的大幅增加有关。这种产科并发症是一种异质性疾病，因为只有一半的患者在羊膜腔内可检测到微生物。由于生物活性脂质在炎症反应的启动和消退中起着关键作用，我们的目的是描述TCC患者羊水脂质组的特征。我们研究了以下几组患者的羊水：1）足月自然分娩无临床绒毛膜炎（TLB）和2）足月自然分娩有临床绒毛膜炎（TCC）。TCC组又分为a）有羊膜腔微生物侵袭（TCC-MIAC）组和B）无羊膜腔微生物侵袭（TCC-noMIAC）组。羊水中促炎性脂质介质的浓度在TLB与TCC患者之间没有差异。相反，具有抗炎/促消退特性的脂质浓度在所有TCC患者中显著低于TLB患者。这些结果表明，虽然促炎脂质介质参与感染驱动的羊膜内炎症，抗炎/促分解脂质介质生物合成的相对不足是TCC的特征。
Clinical chorioamnionitis at term (TCC) is the most common obstetrical infliction diagnosed in labor and delivery units worldwide and is associated with a substantial increase in maternal and neonatal morbidity and mortality. This obstetrical complication is a heterogeneous condition, as only half of patients have detectable microorganisms in the amniotic cavity. Because bioactive lipids play a key role in the initiation and resolution of an inflammatory response, we aimed to characterize the amniotic fluid lipidome in patients with TCC. We studied the amniotic fluid of patients in the following groups: 1) spontaneous labor at term without clinical chorioamnionitis (TLB) and 2) spontaneous labor at term with clinical chorioamnionitis (TCC). The TCC group was subdivided into a) those with microbial invasion of the amniotic cavity (TCC-MIAC) and b) those without microbial invasion of the amniotic cavity (TCC-noMIAC). The amniotic fluid concentration of proinflammatory lipid mediators did not differ between patients in TLB with TCC. In contrast, concentration of lipids with anti-inflammatory/proresolution properties was significantly lower in all patients with TCC than in those with TLB. These results suggest that while proinflammatory lipid mediators are involved in infection-driven intra-amniotic inflammation, a relative deficiency of anti-inflammatory/proresolution lipid mediator biosynthesis is a characteristic of TCC.
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影响因子：
62.1
作者：
Serhan, Charles N.;Petasis, Nicos A.
通讯作者：
Petasis, Nicos A.
影响因子：
2.1
作者：
Tita AT;Andrews WW
通讯作者：
Andrews WW
DOI：
10.1152/ajpheart.2001.280.6.h2430
发表时间：
2001-06
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Yongde Zhang;C. Oltman;T. Lu;Hon-Chi Lee;K. Dellsperger;M. Vanrollins
通讯作者：
Yongde Zhang;C. Oltman;T. Lu;Hon-Chi Lee;K. Dellsperger;M. Vanrollins
影响因子：
5.5
作者：
Colas, Romain A.;Shinohara, Masakazu;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
影响因子：
56.9
作者：
Node, K;Huo, YQ;Liao, JK
通讯作者：
Liao, JK