Maternal KIR in combination with paternal HLA-C2 regulate human birth weight.
Maternal KIR in combination with paternal HLA-C2 regulate human birth weight.
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DOI：
10.4049/jimmunol.1400577
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发表时间：
2014-06-01
期刊：
影响因子：
--
通讯作者：
Moffett A
中科院分区：
文献类型：
--
作者：
Hiby SE;Apps R;Chazara O;Farrell LE;Magnus P;Trogstad L;Gjessing HK;Carrington M;Moffett A
人类出生体重受到稳定选择的影响;出生时太小或太大的婴儿都不太可能存活。母体/胎儿免疫系统基因的特定组合与婴儿≤第5出生体重百分位数的妊娠相关。特别是具有抑制性的母体KIR AA基因型和父系衍生的胎儿HLA-C2配体。我们现在已经分析了母亲KIR和胎儿HLA-C组合在出生体重谱的另一端。对1316对母亲/婴儿进行了母亲KIR以及胎儿和母亲HLA-C的基因分型。在所有妊娠>第5百分位数的线性或逻辑回归分析中，存在与出生体重增加相关的母体激活KIR 2DS 1基因（p=0.005，n=1316）。KIR 2DS 1的作用在其配体HLA-C2由胎儿父系遗传而非母系遗传的妊娠中最显著（p=0.005，OR=2.65）。因此，母体KIR在小婴儿中更经常是抑制性的，而在大婴儿中则是激活性的。在出生体重的两个极端，当他们的HLA-C2配体由胎儿父系遗传时，KIR关联发生。我们的结论是，两个多态性免疫基因系统，KIR和HLA-C，有助于成功的繁殖，通过维持出生体重之间的两个极端与父亲的HLA的明确作用。
Human birth weight is subject to stabilizing selection; babies born too small or too large are less likely to survive. Particular combinations of maternal/fetal immune system genes are associated with pregnancies where the babies are ≤5th birth weight centile. Specifically an inhibitory maternal KIR AA genotype with a paternally derived fetal HLA-C2 ligand. We have now analysed maternal KIR and fetal HLA-C combinations at the opposite end of the birth weight spectrum. 1316 mother/baby pairs were genotyped for maternal KIR as well as fetal and maternal HLA-C. Presence of a maternal activating KIR2DS1 gene associated with increased birth weight, in linear or logistic regression analyses of all pregnancies >5th centile (p=0.005, n=1316). Effect of KIR2DS1 was most significant in pregnancies where its ligand, HLA-C2, was paternally but not maternally inherited by a fetus (p=0.005, OR=2.65). Thus maternal KIR are more frequently inhibitory with small babies but activating with big babies. At both extremes of birth weight the KIR associations occur when their HLA-C2 ligand is paternally inherited by a fetus. We conclude that the two polymorphic immune gene systems, KIR and HLA-C, contribute to successful reproduction by maintaining birth weight between two extremes with a clear role for paternal HLA.
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DOI：
10.1111/j.1469-1809.1951.tb02469.x
发表时间：
1951-01-01
期刊：
ANNALS OF EUGENICS
影响因子：
--
作者：
KARN, MN;PENROSE, LS
通讯作者：
PENROSE, LS
影响因子：
6.1
作者：
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Moffett, A.
影响因子：
13.6
作者：
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通讯作者：
Hoppin, Jane A.
影响因子：
2.5
作者：
Rice, Frances;Thapar, Anita
通讯作者：
Thapar, Anita
DOI：
10.3109/14767058.2013.858241
发表时间：
2014-09-01
影响因子：
1.8
作者：
Curti, Alessandra;Zanello, Margherita;Farina, Antonio
通讯作者：
Farina, Antonio