Periovulatory Subphase of the Menstrual Cycle Is Marked by a Significant Decrease in Heart Rate Variability.
Periovulatory Subphase of the Menstrual Cycle Is Marked by a Significant Decrease in Heart Rate Variability.
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如果在高频（HF）域中测量，心率变异性（HRV）反映了副交感神经系统（PNS）对心率减速的紧张性抑制控制。一些研究已经检查了HF-HRV变异性在月经周期中的变化;然而，他们没有实施最新的技术和统计方法。评估整个月经周期的HF-HRV是重要的，因为在许多情况下观察到低HF-HRV变异性，包括心脏病和抑郁症。此外，如果在排卵前后观察到HF-HRV的变化，则可用于确定受孕时间。这项研究发现，相对于月经周期的所有其他时间，HF-HRV在排卵前后显著降低。这一发现增强了我们对人类生物学的理解。未来的研究可能会检查HF-HRV的下降是否是一个正常的过程，可以在未来利用，以提高生育率，或者它是否代表一个生物过程，可能会使一些妇女的疾病发展。(1)背景资料：高频心率变异性（HF-HRV）是一种基本的超日节律，反映了PNS的活动，使心脏减速。目前尚不清楚HF-HRV在月经周期（MC）中如何变化，以及孕酮是否介导了这种潜在的变化。(2)研究方法：我们招募了33名妇女参加这项研究，在整个MC的8个诊所访问，在此期间，我们测量了他们的静息HF-HRV和收集样本的促黄体生成素（LH）和孕酮的分析。我们根据血清LH峰到卵泡早期、卵泡中期、排卵期、黄体早期、黄体中期和黄体晚期的亚相重新排列研究数据。(3)结果如下：所有亚期之间的成对比较显示，卵泡早期和排卵期亚期之间（β = 0.9302; p ≤ 0.001）以及排卵期和黄体早期亚期之间（β = −0.6955; p ≤ 0.05）存在显著差异。在早期卵泡亚期，预后与HF-HRV呈正相关，但在围排卵亚期，预后与HF-HRV无关（p ≤ 0.05）。(4)结论：本研究显示，在预期排卵时，HF-HRV显著下降。鉴于妇女心血管疾病死亡率很高，在这一领域开展进一步研究至关重要。
If measured in the high-frequency (HF) domain, heart rate variability (HRV) reflects the tonic, inhibitory control by the parasympathetic nervous system (PNS) to decelerate the heart rhythm. Several studies have examined changes in HF-HRV variability across the menstrual cycle; however, they did not implement the latest technological and statistical approaches. The evaluation of HF-HRV across the menstrual cycle is important because low HF-HRV variability is observed in numerous conditions, including heart disease and depression. Moreover, if a change in HF-HRV is observed around ovulation, it may be used to time conception. This study found that HF-HRV significantly decreases around ovulation relative to all other times of the menstrual cycle. This finding enhances our understanding of human biology. Future studies may examine whether the decrease in HF-HRV is a normal process that may be utilized in the future to enhance fertility rates, or whether it represents a biological process that may predispose some women to disease development. (1) Background: High-frequency heart rate variability (HF-HRV) is an essential ultradian rhythm that reflects the activity of the PNS to decelerate the heart. It is unknown how HF-HRV varies across the menstrual cycle (MC), and whether progesterone mediates this potential variation. (2) Methods: We enrolled 33 women in the study to attend eight clinic visits across the MC, during which we measured their resting HF-HRV and collected samples for the analysis of luteinizing hormone (LH) and progesterone. We realigned the study data according to the serum LH surge to the early follicular, mid-follicular, periovulatory, early luteal, mid-luteal and late luteal subphases. (3) Results: Pairwise comparisons between all the subphases showed significant differences between the early follicular and periovulatory subphases (β = 0.9302; p ≤ 0.001) and between the periovulatory and early luteal subphases (β = −0.6955; p ≤ 0.05). Progesterone was positively associated with HF-HRV in the early follicular subphase but not the periovulatory subphase (p ≤ 0.05). (4) Conclusions: The present study shows a significant drop in HF-HRV in the anticipation of ovulation. Further research in this area is critical given the marked cardiovascular disease mortality in women.
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