Areal and volumetric bone mineral density and risk of multiple types of fracture in older men.
Areal and volumetric bone mineral density and risk of multiple types of fracture in older men.
复制标题
DOI：
10.1016/j.bone.2016.08.014
复制
发表时间：
2016-11
期刊：
影响因子：
4.1
通讯作者：
Cauley, Jane A.
中科院分区：
文献类型：
--
作者：
Chalhoub, Didier;Orwoll, Eric S.;Cawthon, Peggy M.;Ensrud, Kristine E.;Boudreau, Robert;Greenspan, Susan;Newman, Anne B.;Zmuda, Joseph;Bauer, Douglas;Cummings, Steven;Cauley, Jane A.
尽管许多研究都探讨了老年男性低骨密度 (BMD) 与骨折风险之间的关系，但没有一项研究同时研究多个 BMD 部位与不同类型骨折风险之间的关系。利用男性骨质疏松性骨折研究的数据，我们在平均 9.7 年的随访期间评估了双能 X 射线吸收测定法 (DXA) 测定的面积 BMD (aBMD) 和定量计算机断层扫描 (QCT) 测量的体积 BMD (vBMD) 与不同类型骨折之间的关联。男性每 4 个月回答一次有关骨折的调查问卷（完成率 >97%）。通过集中审查射线照相报告确认骨折；排除病理性骨折。评估髋部、脊柱、腕部、肩部、肋骨/胸部/胸骨、踝/脚/脚趾、手臂、手/手指、腿、骨盆/尾骨、头骨/面部和任何非脊柱骨折的骨折风险。使用年龄和种族调整后的 Cox 比例风险模型来评估 3301 名老年男性的骨折风险，同时测量 aBMD（股骨颈 (FN) 和腰椎）和 vBMD（小梁脊柱、FN 和皮质 FN）测量值，并以每标准差 (SD) 降低的风险比 (HR) 表示。较低的 FN 和脊柱 aBMD 与髋部、脊柱、腕部、肩部、肋骨/胸部/胸骨、手臂和任何非脊柱骨折的骨折风险增加相关（每 SD 降低的统计显着 HR 范围为 1.24 - 3.57）。较低的脊柱小梁和 FN vBMD 与大多数骨折的风险增加相关，HR 范围在 1.27 至 3.69 之间，具有统计学显着性。 FN 皮质 vBMD 与髋部 (HR=1.55) 和脊柱部位 (HR=1.26) 骨折风险之间存在统计学显着相关性，但与其他骨折部位没有相关性。总之，较低的 aBMD 和 vBMD 均与骨折风险增加相关。小梁 vBMD 观察到的关联性比皮质 vBMD 更强，可能反映了小梁室的代谢活动更大。
Although many studies have examined the association between low bone mineral density (BMD) and fracture risk in older men, none have simultaneously studied the relationship between multiple BMD sites and risk of different types of fractures. Using data from the Osteoporotic Fractures in Men study, we evaluated the association between areal BMD (aBMD) by dual-energy X-ray absorptiometry (DXA) and volumetric BMD (vBMD) by quantitative computed tomography (QCT) measurements, and different types of fractures during an average of 9.7 years of follow up. Men answered questionnaires about fractures every 4 months (>97% completions). Fractures were confirmed by centralized review of radiographic reports; pathological fractures were excluded. Risk of fractures was assessed at the hip, spine, wrist, shoulder, rib/chest/sternum, ankle/foot/toe, arm, hand/finger, leg, pelvis/coccyx, skull/face and any non-spine fracture. Age and race adjusted Cox proportional-hazards modeling was used to assess the risk of fracture in 3301 older men with both aBMD (at the femoral neck (FN) and lumbar spine) and vBMD (at the trabecular spine and FN, and cortical FN) measurements, with hazard ratios (HRs) expressed per standard deviation (SD) decrease. Lower FN and spine aBMD were associated with an increased risk of fracture at the hip, spine, wrist, shoulder, rib/chest/sternum, arm, and any non-spine fracture (statistically significant HRs per SD decrease ranged from 1.24 - 3.57). Lower trabecular spine and FN vBMD were associated with increased risk of most fractures with statistically significant HRs ranging between 1.27 and 3.69. There was a statistically significant association between FN cortical vBMD and fracture risk at the hip (HR=1.55) and spine sites (HR=1.26), but no association at other fracture sites. In summary, both lower aBMD and vBMD were associated with increased fracture risk. The stronger associations observed for trabecular vBMD than cortical vBMD may reflect the greater metabolic activity of the trabecular compartment.
登录
查看更多内容
影响因子：
2.8
作者：
Chen H;Zhou X;Fujita H;Onozuka M;Kubo KY
通讯作者：
Kubo KY
影响因子：
6.2
作者：
Marshall, Lynn M.;Lang, Thomas F.;Orwoll, Eric S.
通讯作者：
Orwoll, Eric S.
影响因子：
4.2
作者：
Cawthon, Peggy M.
通讯作者：
Cawthon, Peggy M.
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K
影响因子：
4
作者：
Looker, A. C.;Melton, L. J., III;Shepherd, J. A.
通讯作者：
Shepherd, J. A.