Thinking Small: Progress on Microscale Neurostimulation Technology.
Thinking Small: Progress on Microscale Neurostimulation Technology.
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DOI：
10.1111/ner.12716
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Cogan SF
中科院分区：
文献类型：
--
作者：
Pancrazio JJ;Deku F;Ghazavi A;Stiller AM;Rihani R;Frewin CL;Varner VD;Gardner TJ;Cogan SF
神经刺激被广泛接受为一种有效的治疗各种神经系统疾病。虽然临床设备的规模相对较大，但基于微电极的系统的转化和试点临床应用正在进行中。微电极具有刺激相对小的组织体积的优点，这可以提高治疗刺激的选择性。目前的微电极技术与慢性组织反应相关，这限制了这些装置用于神经记录和刺激的效用。用于解决组织反应问题的一种方法可以是减小装置的物理尺寸。“从小处着眼”是电子行业的一种趋势，对于植入式神经接口来说，其结果可能是一种可以逃避异物反应的设备。本文综述了我们目前对植入物尺寸和组织反应之间关系的理解以及超小微电极的最新技术。使用PubMed、Web of Science（Clarivate Analytics）和Google Scholar进行了全面的文献检索。文献综述表明，最近的努力，创造微电极是非常薄的出现，以减少甚至消除慢性组织反应。随着高电荷容量涂层，超微电极制成的新兴聚合物和无定形碳化硅神经刺激应用程序出现有前途的。我们设想出现强大的和可制造的超微电极，利用先进的材料，其中小的横截面几何形状使组织内的顺应性。然而，未来在体内条件下的测试对于评估薄膜装置在慢性刺激下的稳定性特别重要。
Neural stimulation is well-accepted as an effective therapy for a wide range of neurological disorders. While the scale of clinical devices is relatively large, translational and pilot clinical applications are underway for microelectrode-based systems. Microelectrodes have the advantage of stimulating a relatively small tissue volume which may improve selectivity of therapeutic stimuli. Current microelectrode technology is associated with chronic tissue response which limits utility of these devices for neural recording and stimulation. One approach for addressing the tissue response problem may be to reduce physical dimensions of the device. “Thinking small” is a trend for the electronics industry, and for implantable neural interfaces, the result may be a device that can evade the foreign body response. This review paper surveys our current understanding pertaining to the relationship between implant size and tissue response and the state-of-the-art in ultra-small microelectrodes. A comprehensive literature search was performed using PubMed, Web of Science (Clarivate Analytics), and Google Scholar. The literature review shows recent efforts to create microelectrodes that are extremely thin appear to reduce or even eliminate the chronic tissue response. With high charge capacity coatings, ultra-microelectrodes fabricated from emerging polymers and amorphous silicon carbide appear promising for neurostimulation applications. We envision the emergence of robust and manufacturable ultra-microelectrodes that leverage advanced materials where the small cross-sectional geometry enables compliance within tissue. Nevertheless, future testing under in vivo conditions is particularly important for assessing the stability of thin film devices under chronic stimulation.
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DOI：
10.1002/jbm.b.31223
发表时间：
2009-05
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Cogan SF;Ehrlich J;Plante TD;Smirnov A;Shire DB;Gingerich M;Rizzo JF
通讯作者：
Rizzo JF
影响因子：
4.9
作者：
Cogan, SF;Edell, DJ;Edell, R
通讯作者：
Edell, R
影响因子：
4.2
作者：
Frost, Shawn B.;Dunham, Caleb L.;Nudo, Randolph J.
通讯作者：
Nudo, Randolph J.
影响因子：
9.9
作者：
Contarino, M. Fiorella;Bour, Lo J.;Schuurman, P. R.
通讯作者：
Schuurman, P. R.
影响因子：
4
作者：
Davis, T. S.;Wark, H. A. C.;Greger, B.
通讯作者：
Greger, B.