Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?
Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?
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DOI：
10.1016/j.ijantimicag.2011.05.004
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发表时间：
2011-09
影响因子：
10.8
通讯作者：
Brogden KA
中科院分区：
文献类型：
--
作者：
Brogden NK;Brogden KA
抗微生物肽（AMP）作为有效药物的概念在文献中牢固确立，并且关于该主题的大多数研究文章的结论是指出AMP代表有前途的针对细菌和真菌剂的治疗剂。事实上，该领域的早期研究表明，AMP在性质上是多样的，具有高活性和低的最小抑制浓度，对细菌、真菌和病毒病原体具有广谱活性，并且可以容易地被操纵以改变它们的特异性，降低它们的细胞毒性并增加它们的抗微生物活性。不幸的是，这些肽的商业开发，即使是最简单的应用，也非常有限。对于一些肽，在其制造、体内功效和体内保留方面存在障碍。最近，焦点已经转移。当代研究现在使用更复杂的方法来开发AMP，克服了许多这些先前的障碍。AMP模拟物、杂合AMP、AMP同源物、环肽和稳定的AMP、AMP缀合物和固定的AMP都具有选择性或“靶向”抗微生物活性、改善的保留或允许它们结合到医疗或工业表面的独特能力。这些新的肽具有创造性的医疗和工业应用潜力，以治疗耐药细菌感染和败血性休克，保存食品或在体外和体内消毒表面。
The concept of antimicrobial peptides (AMPs) as potent pharmaceuticals is firmly established in the literature, and most research articles on this topic conclude by stating that AMPs represent promising therapeutic agents against bacterial and fungal agents. Indeed, early research in this field showed that AMPs were diverse in nature, had high activities with low minimal inhibitory concentrations, had broad spectrums of activity against bacterial, fungal and viral pathogens, and could easily be manipulated to alter their specificities, reduce their cytotoxicities and increase their antimicrobial activities. Unfortunately, commercial development of these peptides, for even the simplest of applications, has been very limited. With some peptides there are obstacles with their manufacture, in vivo efficacy and in vivo retention. More recently, the focus has shifted. Contemporary research now uses a more sophisticated approach to develop AMPs that surmount many of these prior obstacles. AMP mimetics, hybrid AMPs, AMP congeners, cyclotides and stabilised AMPs, AMP conjugates and immobilised AMPs have all emerged with selective or ‘targeted’ antimicrobial activities, improved retention, or unique abilities that allow them to bind to medical or industrial surfaces. These groups of new peptides have creative medical and industrial application potentials to treat antibiotic-resistant bacterial infections and septic shock, to preserve food or to sanitise surfaces both in vitro and in vivo.
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影响因子：
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