The Association between Epidermal Growth Factor Receptor (EGFR) Gene Polymorphisms and Lung Cancer Risk.
The Association between Epidermal Growth Factor Receptor (EGFR) Gene Polymorphisms and Lung Cancer Risk.
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DOI：
10.3390/biom8030053
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发表时间：
2018-07-13
期刊：
影响因子：
5.5
通讯作者：
Momani JA
中科院分区：
文献类型：
--
作者：
Bashir NA;Ragab ES;Khabour OF;Khassawneh BY;Alfaqih MA;Momani JA
肺癌是全球癌症死亡的主要原因。表皮生长因子受体（EGFR）在细胞增殖和信号传导中起重要作用。在这项研究中，我们研究了约旦人群中EGFR基因多态性与肺癌风险之间的关系。本研究共招募了129例原发性肺癌患者和129例匹配的健康对照。EGFR rs712829、rs712830、rs2072454和rs11543848单核苷酸多态性（SNP）基因分型，以检测其与肺癌风险的相关性。在rs712829 SNP与肺癌风险之间观察到显著关联（p < 0.05），其中与对照相比，肺癌患者中GG + GT基因型更高。此外，未检测到rs712830、rs2072454和rs11543848 SNP与肺癌风险之间的关联。当患者根据肺癌类型分层时，检测到rs712829和rs2072454与腺癌肺癌之间的显著关联（p < 0.05）。所有四种SNPs的单倍型分析显示TCCG单倍型与肺癌和腺癌亚型之间存在显著关联（p < 0.001）。总之，EGFR rs712829、rs2072454 SNP和TCCG单倍型与约旦人肺癌风险相关。由于遗传关联受人口遗传背景的影响，需要在其他阿拉伯人口中进行更多的研究，以证实目前的研究结果。
Lung cancer is the leading cause of cancer death globally. The epidermal growth factor receptor (EGFR) plays an important role in cell proliferation and signaling. In this study, we examined the association between EGFR gene polymorphisms and lung cancer risk among the Jordanian population. A total of 129 patients with primary lung cancer and 129 matched healthy controls were recruited into this study. EGFR rs712829, rs712830, rs2072454, and rs11543848 single nucleotide polymorphisms (SNPs) were genotyped to test for their association with lung cancer risk. A significant association was observed between the rs712829 SNP and lung cancer risk (p < 0.05) where the GG + GT genotypes were higher in lung cancer patients when compared to controls. In addition, no association was detected between rs712830, rs2072454, and rs11543848 SNPs and lung cancer risk. When patients were stratified according to the lung cancer type, a significant association was detected between both rs712829 and rs2072454 and adenocarcinoma lung cancer (p < 0.05). Haplotype analysis of all four SNPs showed a significant association between the TCCG haplotype and both lung cancer and the adenocarcinoma subtype (p < 0.001). In conclusion, EGFR rs712829, rs2072454 SNPs, and TCCG haplotypes are associated with a risk of lung cancer among Jordanians. Since genetic associations are affected by the genetic background of populations, more studies in other Arab populations are required to confirm the present findings.
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DOI：
10.1016/j.mcna.2017.03.008
发表时间：
2017-07
期刊：
The Medical clinics of North America
影响因子：
--
作者：
Hoffman RM;Sanchez R
通讯作者：
Sanchez R
影响因子：
4.7
作者：
Rahal Z;El Nemr S;Sinjab A;Chami H;Tfayli A;Kadara H
通讯作者：
Kadara H
个体 KIAA0319 多态性与人群中发育性阅读障碍风险之间的相反关联：研究人群的分层荟萃分析
影响因子：
4.6
作者：
Shao S;Niu Y;Zhang X;Kong R;Wang J;Liu L;Luo X;Zhang J;Song R
通讯作者：
Song R
影响因子：
2.7
作者：
Khabour OF;Abu-Rumeh L;Al-Jarrah M;Jamous M;Alhashimi F
通讯作者：
Alhashimi F
影响因子：
2.7
作者：
Shitara M;Sasaki H;Yokota K;Okuda K;Hikosaka Y;Moriyama S;Yano M;Kawaguchi T;Kubo A;Takada M;Kitahara N;Okumura M;Matsumura A;Iuchi K;Fujii Y
通讯作者：
Fujii Y