Salivary Testosterone Levels and Health Status in Men and Women in the British General Population: Findings from the Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).
Salivary Testosterone Levels and Health Status in Men and Women in the British General Population: Findings from the Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).
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DOI：
10.1210/jc.2016-1669
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Wu FC
中科院分区：
文献类型：
--
作者：
Clifton S;Macdowall W;Copas AJ;Tanton C;Keevil BG;Lee DM;Mitchell KR;Field N;Sonnenberg P;Bancroft J;Mercer CH;Wallace AM;Johnson AM;Wellings K;Wu FC
唾液T（Sal-T）测量液相色谱-串联质谱法显示有机会检查健康相关的Sal-T在大规模的人口调查。本研究旨在研究年龄在18-74岁之间的男性和女性的Sal-T和健康相关因素之间的关联。早晨的唾液样本来自英国普通人群的横断面概率抽样调查（Natsal-3）的参与者。自我报告的健康和生活方式问题作为更广泛的性健康访谈的一部分进行管理。研究参与者包括1599名男性和2123名女性。使用液相色谱-串联质谱法测量Sal-T。线性回归用于检查健康因素与平均Sal-T之间的关联。在男性中，平均Sal-T与年龄调整后的一系列健康因素相关，并在多变量分析中与体重指数（BMI）呈强独立负相关。报告心血管疾病或正在服用抑郁症药物的男性年龄调整后的Sal-T较低，尽管在调整BMI后与心血管疾病无关。在调整健康相关因素后，随着年龄的增长，盐T的下降仍然存在。在女性中，Sal-T随着年龄的增长而下降;然而，除了吸烟者的Sal-T较高外，与健康相关因素或特定健康状况没有年龄无关的关联。男性的Sal-T水平与一系列自我报告的健康标志物（特别是BMI）相关，与年龄无关，但与女性无关。研究结果支持了这样一种观点，即男性和女性的Sal-T与年龄有关，这不能用健康状况不佳的增加来解释。我们的研究结果表明，作为一个方便的测量组织雄激素暴露的人口研究的潜力。在一项普通人群研究中，Sal-T水平与男性BMI相关。研究发现，男性和女性的Sal-T与年龄有关，这不能用健康状况不佳的增加来解释。
Salivary T (Sal-T) measurement by liquid chromatography–tandem mass spectroscopy resents the opportunity to examine health correlates of Sal-T in a large-scale population survey. This study sought to examine associations between Sal-T and health-related factors in men and women age 18–74 years. Morning saliva samples were obtained from participants in a cross-sectional probability-sample survey of the general British population (Natsal-3). Self-reported health and lifestyle questions were administered as part of a wider sexual health interview. Study participants included 1599 men and 2123 women. Sal-T was measured using liquid chromatography–tandem mass spectroscopy. Linear regression was used to examine associations between health factors and mean Sal-T. In men, mean Sal-T was associated with a range of health factors after age adjustment, and showed a strong independent negative association with body mass index (BMI) in multivariable analysis. Men reporting cardiovascular disease or currently taking medication for depression had lower age-adjusted Sal-T, although there was no association with cardiovascular disease after adjustment for BMI. The decline in Sal-T with increasing age remained after adjustment for health-related factors. In women, Sal-T declined with increasing age; however, there were no age-independent associations with health-related factors or specific heath conditions with the exception of higher Sal-T in smokers. Sal-T levels were associated, independently of age, with a range of self-reported health markers, particularly BMI, in men but not women. The findings support the view that there is an age-related decline in Sal-T in men and women, which cannot be explained by an increase in ill health. Our results demonstrate the potential of Sal-T as a convenient measure of tissue androgen exposure for population research. Sal-T levels in a general population study were associated with BMI in men. An agerelated decline in Sal-T in men and women was found which cannot be explained by an increase in ill-health
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