FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases.
FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases.
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DOI：
10.3389/fendo.2014.00107
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发表时间：
2014
影响因子：
5.2
通讯作者：
Itoh N
中科院分区：
文献类型：
--
作者：
Itoh N
成纤维细胞生长因子（FGF）家族成员主要作为信号蛋白分泌，在发育和代谢中具有多种功能。FGF 21是一种独特的FGF，具有代谢活性，但不具有增殖活性。FGF 21主要由不同种类的应激诱导，并通过FGF受体1c与作为辅因子的β-Klotho以内分泌或部分自分泌/旁分泌方式起作用。肝FGF 21直接作用于白色脂肪细胞以抑制脂解，并通过脑作用以增加全身糖皮质激素水平并抑制响应饥饿的身体活动。它还可以防止二恶英的毒性。脂肪细胞FGF 21诱导白色脂肪组织（WAT）的布朗宁，并激活棕色脂肪细胞以响应冷暴露。在白色脂肪细胞中也作为脂联素的上游效应物。肌细胞FGF 21可防止饮食诱导的肥胖和胰岛素抵抗，诱导WAT的布朗宁，并防止心脏肥大。此外，Fgf 21基因多态性可能与代谢性疾病有关，是代谢性疾病的生物标志物。这些发现表明FGF 21作为肝细胞因子、脂肪细胞因子和肌细胞因子在代谢、损伤保护和疾病中发挥作用。
Fibroblast growth factor (FGF) family members are mostly secreted as signaling proteins with diverse functions in development and metabolism. FGF21 is a unique FGF with metabolic, but not proliferative activities. FGF21 is mostly induced by different kinds of stress and acts though FGF receptor 1c with β-Klotho as a cofactor in an endocrine or, in parts, autocrine/paracrine manner. Hepatic FGF21 directly acts on white adipocytes to inhibit lipolysis and acts through the brain to increase systemic glucocorticoid levels and suppress physical activity in response to starvation. It also protects against dioxin toxicity. Adipocytic FGF21 induces the browning of white adipose tissue (WAT) and activates brown adipocytes in response to cold exposure. It also acts as an upstream effector of adiponectin in white adipocytes. Myocytic FGF21 protects against diet-induced obesity and insulin resistance, induces the browning of WAT, and protects against cardiac hypertrophy. In addition, Fgf21 polymorphisms are possibly related with metabolic diseases and FGF21 are biomarker of metabolic diseases. These findings indicate that FGF21 plays roles as a hepatokine, adipokine, and myokine in metabolism, injury protection, and diseases.
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影响因子：
5.2
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通讯作者：
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