Causal role of prefrontal cortex in strengthening of episodic memories through reconsolidation.
Causal role of prefrontal cortex in strengthening of episodic memories through reconsolidation.
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DOI：
10.1016/j.cub.2013.08.045
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发表时间：
2013-11-04
期刊：
影响因子：
9.2
通讯作者：
Cohen, Leonardo G.
中科院分区：
文献类型：
--
作者：
Sandrini, Marco;Censor, Nitzan;Mishoe, Jonathan;Cohen, Leonardo G.
记忆巩固是一个动态的过程。重新激活合并的记忆会触发重新合并，这是一个时间限制的时期，在此期间可以修改记忆。情节记忆是指我们回忆关于发生了什么的特定过去事件的能力，包括时间和地点。然而，目前尚不清楚在再巩固过程中对新皮质的非侵入性刺激是否会增强人类现有的情景记忆。为了改善这些记忆，我们对右侧前额叶皮质(PFC)进行了重复的经颅磁刺激(RTMS)，这一区域参与了情景记忆的重新激活。我们报告了记忆重新激活后的PFC的rTMS增强了言语情景记忆，与未重新激活的PFC刺激和重新激活后的Vertex(对照部位)相比，重新激活后24小时的改善回忆证明了这种效果。相反，再激活后1h的刺激没有作用(对照实验)，表明记忆强化是时间依赖的，与再巩固理论一致。因此，我们证明了右侧PFC在人类通过再巩固强化情节记忆中起着因果作用。重新巩固可以作为一个机会，通过对关键大脑区域的非侵入性刺激来修改现有的记忆，这是一个对记忆研究和临床应用至关重要的问题。
Memory consolidation is a dynamic process. Reactivation of consolidated memories triggers reconsolidation, a time-limited period during which memories can be modified. Episodic memory refers to our ability to recall specific past events about what happened, including where and when. However, it is unknown whether non-invasive stimulation of the neocortex during reconsolidation might strengthen existing episodic memories in humans. To modify these memories, we applied repetitive transcranial magnetic stimulation (rTMS) over right lateral prefrontal cortex (PFC), a region involved in the reactivation of episodic memories . We report that rTMS of PFC after memory reactivation strengthened verbal episodic memories, an effect documented by improved recall 24h post-reactivation compared to stimulation of PFC without reactivation and Vertex (control site) after reactivation. In contrast, there was no effect of stimulation 1h post-reactivation (control experiment), showing that memory strengthening is time-dependent, consistent with the reconsolidation theory. Thus, we demonstrated that right lateral PFC plays a causal role in strengthening of episodic memories through reconsolidation in humans. Reconsolidation may serve as an opportunity to modify existing memories with non-invasive stimulation of a critical brain region, an issue of fundamental importance for memory research and clinical applications.
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影响因子：
9.2
作者：
Censor, Nitzan;Dimyan, Michael A.;Cohen, Leonardo G.
通讯作者：
Cohen, Leonardo G.
影响因子：
2
作者：
Hupbach, Almut;Hardt, Oliver;Nadel, Lynn
通讯作者：
Nadel, Lynn
影响因子：
3.2
作者：
Sandrini, M;Cappa, SF;Miniussi, C
通讯作者：
Miniussi, C
影响因子：
64.8
作者：
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通讯作者：
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影响因子：
2.9
作者：
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通讯作者：
Cipolotti L