Closing the brain-heart loop: Towards more holistic models of addiction and addiction recovery.
Closing the brain-heart loop: Towards more holistic models of addiction and addiction recovery.
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DOI：
10.1111/adb.12958
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发表时间：
2022-01
影响因子：
3.4
通讯作者：
Buckman JF
中科院分区：
文献类型：
--
作者：
Eddie D;Bates ME;Buckman JF
许多研究试图阐明成瘾和成瘾恢复所涉及的大脑结构和途径。著名的神经生物学模型强调大脑皮层和边缘系统区域之间的相互作用是成瘾过程的主要驱动力，但在很大程度上没有考虑将情境和状态与大脑和行为联系起来的感觉和内脏信息流。然而，这些脑-体信息流似乎是成瘾综合模型的必要元素。作为一个出发点，我们描述了一个当前模型的成瘾电路和神经网络，不仅调节心血管系统的活动，但也通过压力反射环接收来自外周心血管过程的反馈之间的重叠。我们强调需要神经和外周心血管信号整合的神经生物学，分子和行为研究的经验，内部状态和环境背景下，驱动酒精和其他药物使用行为。最后，我们呼吁进行系统的、机械的研究，研究神经科学信息的成瘾治疗的好处，这些干预措施针对心血管系统的可塑性来改变大脑过程。
Much research seeks to articulate the brain structures and pathways implicated in addiction and addiction recovery. Prominent neurobiological models emphasize the interplay between cortical and limbic brain regions as a main driver of addictive processes, but largely do not take into consideration sensory and visceral information streams that link context and state to the brain and behavior. Yet these brain–body information streams would seem to be necessary elements of a comprehensive model of addiction. As a starting point, we describe the overlap between one current model of addiction circuitry and the neural network that not only regulates cardiovascular system activity but also receives feedback from peripheral cardiovascular processes through the baroreflex loop. We highlight the need for neurobiological, molecular, and behavioral studies of neural and peripheral cardiovascular signal integration during the experience of internal states and environmental contexts that drive alcohol and other drug use behaviors. We end with a call for systematic, mechanistic research on the promising, yet largely unexamined benefits to addiction treatment of neuroscience-informed, adjunctive interventions that target the malleability of the cardiovascular system to alter brain processes.
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影响因子：
5.5
作者：
Eddie, David;Greene, M. Claire;Kelly, John F.
通讯作者：
Kelly, John F.
DOI：
10.1037/amp0000232
发表时间：
2018-11
期刊：
The American psychologist
影响因子：
--
作者：
Gianaros PJ;Jennings JR
通讯作者：
Jennings JR
影响因子：
2.9
作者：
Eddie, David;Vaschillo, Evgeny;Lehrer, Paul
通讯作者：
Lehrer, Paul
影响因子：
4.4
作者：
Eddie, D.;Buckman, J. F.;Mun, E. Y.;Vaschillo, B.;Vaschillo, E.;Udo, T.;Lehrer, P.;Bates, M. E.
通讯作者：
Bates, M. E.
DOI：
10.1098/rstb.1996.0125
发表时间：
1996-10-29
影响因子：
6.3
作者：
Damasio, AR
通讯作者：
Damasio, AR