Surface zwitterionically functionalized PVA-co-PE nanofiber materials by click chemistry
Surface zwitterionically functionalized PVA-co-PE nanofiber materials by click chemistry
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通过点击化学对 PVA-co-PE 纳米纤维材料进行表面两性离子功能化
DOI：
10.1039/c3ra41505h
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发表时间：
2013-10
期刊：
影响因子：
3.9
通讯作者：
Weilin Xu
中科院分区：
文献类型：
--
作者：
Jingjing Huang;Dong Wang;Ying Lu;Mufang Li;Weilin Xu
将两性离子材料应用于纳米纤维表面以防止生物分子与微生物的非特异性黏附，是高效生物传感器和亲和膜的需要。本文采用两种合成路线对两性离子磺基甜菜碱在PVA-co-PE纳米纤维膜表面的官能化进行了研究。用三聚氯氰活化PVA-co-PE纳米纤维膜，然后用叠氮化钠或2-丙基胺对其进行表面官能化处理，制得含叠氮基或炔基的可点击纳米纤维。两性离子磺基甜菜碱最终被“点击”到PVA-co-PE纳米纤维膜上。用FTIR-ATR、拉曼光谱、XPS和EDS对PVA-co-PE纳米纤维膜进行了表面官能化处理。元素组成的XPS分析表明，活化的PVA-co-PE纳米纤维膜的烷基化作用比表面叠氮化作用能在纳米纤维表面“点击”更多的磺基甜菜碱。扫描电子显微镜结果表明，功能化的PVA-co-PE纳米纤维膜保持了良好的纳米纤维形态。含有两性离子磺基甜菜碱的PVA-co-PE纳米纤维膜通过有效地阻止牛血清白蛋白(BSA)的吸附而显示出优异的防污染性能。
Antifouling nanofibers with zwitterionic materials on surfaces that can prevent the nonspecific adhesion of biomolecules and microorganism are in demand for high efficiency biosensors and affinity membranes. The functionalization of zwitterionic sulfobetaine on surfaces of PVA-co-PE nanofiber membrane via click chemistry is performed employing two synthesis routes and reported in this paper. PVA-co-PE nanofiber membranes were activated with cyanuric chloride, and then surface functionalized with sodium azide or 2-propynylamine to prepare “clickable” nanofibers with azide or alkynyl groups, respectively. The zwitterionic sulfobetaine was finally “clicked” onto PVA-co-PE nanofiber membranes. The successful surface functionalizations of PVA-co-PE nanofiber membrane were confirmed with FTIR-ATR, Raman spectroscopy, XPS and EDS. The analysis of element composition using XPS indicated that alkynylation of activated PVA-co-PE nanofiber membranes can “click” more sulfobetaines on nanofiber surfaces than surface azidation. SEM results showed that functionalized PVA-co-PE nanofiber membranes maintained well-defined nanofibrous morphology. PVA-co-PE nanofiber membranes with zwitterionic sulfobetaine demonstrated excellent antifouling performance by effectively resisting bovine serum albumin (BSA) protein adsorption.
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影响因子：
4.6
作者：
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