The control of male fertility by spermatozoan ion channels.
The control of male fertility by spermatozoan ion channels.
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DOI：
10.1146/annurev-physiol-020911-153258
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发表时间：
2012
影响因子：
18.2
通讯作者：
Clapham DE
中科院分区：
文献类型：
--
作者：
Lishko PV;Kirichok Y;Ren D;Navarro B;Chung JJ;Clapham DE
离子通道通过调节女性生殖道中的精子成熟和触发成功受精所需的关键精子生理反应（如过度激活的运动性、趋化性和顶体反应）来控制精子与卵子受精的能力。CatSper是一种ph调节的钙选择性离子通道，KSper （Slo3）是精子尾部钙进入和精子过度激活运动的核心调节剂。在没有直接测量的情况下，许多其他的通道被认为是调节精子活动的。随着精子膜片钳技术的发展，已证实CatSper和KSper是精子的主要离子通道。此外，在人类精子尾部发现了电压门控质子通道Hv1，在小鼠精子中段发现了P2X2离子通道。精子特异性离子通道的突变和缺失会影响小鼠和人类的雄性生育能力，而不会影响其他生理功能。精子离子通道的独特性使其成为避孕的理想药物靶点。本文就离子通道如何调控精子生理进行综述。
Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in the female reproductive tract and by triggering key sperm physiological responses required for successful fertilization such as hyperactivated motility, chemotaxis, and the acrosome reaction. CatSper, a pH-regulated, calcium-selective ion channel, and KSper (Slo3) are core regulators of sperm tail calcium entry and sperm hyperactivated motility. Many other channels had been proposed as regulating sperm activity without direct measurements. With the development of the sperm patch-clamp technique, CatSper and KSper have been confirmed as the primary spermatozoan ion channels. In addition, the voltage-gated proton channel Hv1 has been identified in human sperm tail, and the P2X2 ion channel has been identified in the midpiece of mouse sperm. Mutations and deletions in sperm-specific ion channels affect male fertility in both mice and humans without affecting other physiological functions. The uniqueness of sperm ion channels makes them ideal pharmaceutical targets for contraception. In this review we discuss how ion channels regulate sperm physiology.
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DOI：
10.1083/jcb.134.3.637
发表时间：
1996-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Arnoult C;Zeng Y;Florman HM
通讯作者：
Florman HM
影响因子：
7.8
作者：
BROKAW, CJ
通讯作者：
BROKAW, CJ
影响因子：
6.7
作者：
Banks, Frederick C. L.;Calvert, Robert C.;Burnstock, Geoffrey
通讯作者：
Burnstock, Geoffrey
影响因子：
2.7
作者：
COOK, SP;BROKAW, CJ;BABCOCK, DF
通讯作者：
BABCOCK, DF
影响因子：
10.7
作者：
Cai X;Clapham DE
通讯作者：
Clapham DE