Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study.
Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study.
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母亲在怀孕期间接触苯和 PM10 是否会增加先天畸形的风险？
DOI：
10.1016/j.scitotenv.2015.09.051
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Nicolini,Fausto
中科院分区：
文献类型：
--
作者：
Vinceti,Marco;Malagoli,Carlotta;Malavolti,Marcella;Cherubini,Andrea;Maffeis,Giuseppe;Rodolfi,Rossella;Heck,JuliaE;Astolfi,Gianni;Calzolari,Elisa;Nicolini,Fausto
一些研究表明，母亲暴露于车辆交通造成的环境空气污染与后代先天性畸形风险之间存在关联，但流行病学证据既不强有力，也不完全一致。在意大利北方社区进行的一项基于人群的病例对照研究中，包括228例出生缺陷病例和228例新生儿，我们调查了母亲在怀孕早期暴露于机动车交通中的PM10和苯，通过分散模型估计，是否与过度致畸风险相关。在条件Logistic回归分析中，并调整了其他污染物，我们发现暴露于PM10而不是苯中与出生缺陷风险增加有关。显示与PM10暴露最强剂量-反应关系的异常类别是肌肉骨骼和染色体异常，但不是心血管缺陷，唐氏综合征是显示最强关联的特定异常之一，尽管风险估计，特别是对不太常见的缺陷的风险估计在统计上非常不稳定。在回归模型中对潜在混杂因素进行进一步调整并没有显著改变结果。所有的协会都强于其最高level.Findings的PM10的平均水平，这项研究的结果提供了一些支持，母亲在怀孕期间暴露于PM10，但不是苯的过度致畸风险。这种关联似乎仅限于某些出生缺陷类别。
A few studies have suggested an association between maternal exposure to ambient air pollution from vehicular traffic and risk of congenital anomalies in the offspring, but epidemiologic evidence is neither strong nor entirely consistent.In a population-based case–control study in a Northern Italy community encompassing 228 cases of birth defects and 228 referent newborns, we investigated if maternal exposure to PM10and benzene from vehicular traffic during early pregnancy, as estimated through a dispersion model, was associated with excess teratogenic risk.In conditional logistic regression analysis, and with adjustment for the other pollutant, we found that higher exposure to PM10but not benzene was associated with increased risk of birth defects overall. Anomaly categories showing the strongest dose–response relation with PM10exposure were musculoskeletal and chromosomal abnormalities but not cardiovascular defects, with Down syndrome being among the specific abnormalities showing the strongest association, though risk estimates particularly for the less frequent defects were statistically very unstable. Further adjustment in the regression model for potential confounders did not considerably alter the results. All the associations were stronger for average levels of PM10than for their maximal level.Findings of this study give some support for an excess teratogenic risk following maternal exposure during pregnancy to PM10, but not benzene. Such association appears to be limited to some birth defect categories.
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影响因子：
13.6
作者：
G. Cocchi;C. Magnani;M. Morini;G. Garani;M. Milan;E. Calzolari;Imer Group
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影响因子：
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影响因子：
13.6
作者：
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DOI：
10.3390/ijerph110201398
发表时间：
2014-01-27
影响因子：
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作者：
Rovelli S;Cattaneo A;Nuzzi CP;Spinazzè A;Piazza S;Carrer P;Cavallo DM
通讯作者：
Cavallo DM