Dopamine receptor activation reorganizes neuronal ensembles during hippocampal sharp waves in vitro.
Dopamine receptor activation reorganizes neuronal ensembles during hippocampal sharp waves in vitro.
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DOI：
10.1371/journal.pone.0104438
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Ikegaya Y
中科院分区：
文献类型：
--
作者：
Miyawaki T;Norimoto H;Ishikawa T;Watanabe Y;Matsuki N;Ikegaya Y
海马尖波（SW）/涟漪复合体被认为有助于记忆巩固。以往的研究表明，行为奖励促进SW在体内的发生。然而，人们对这种增强的确切机制知之甚少。在这里，我们研究了多巴胺能神经调节对急性海马脑片自发发生的SW的影响。从CA 1区域记录局部场电位。短暂（1分钟）多巴胺治疗导致事件频率和SW幅度持续增加。这种效应至少持续了我们的记录期45分钟，并没有发生在多巴胺D1/D5受体拮抗剂的存在。功能性多神经元钙成像显示多巴胺诱导的SW增强与SW事件中的放电模式的丰富库相关，而个体神经元参与SW的总体趋势和参与单个SW的细胞的平均数保持不变。因此，多巴胺能激活可能在SW期间重组细胞组装。
Hippocampal sharp wave (SW)/ripple complexes are thought to contribute to memory consolidation. Previous studies suggest that behavioral rewards facilitate SW occurrence in vivo. However, little is known about the precise mechanism underlying this enhancement. Here, we examined the effect of dopaminergic neuromodulation on spontaneously occurring SWs in acute hippocampal slices. Local field potentials were recorded from the CA1 region. A brief (1 min) treatment with dopamine led to a persistent increase in the event frequency and the magnitude of SWs. This effect lasted at least for our recording period of 45 min and did not occur in the presence of a dopamine D1/D5 receptor antagonist. Functional multineuron calcium imaging revealed that dopamine-induced SW augmentation was associated with an enriched repertoire of the firing patterns in SW events, whereas the overall tendency of individual neurons to participate in SWs and the mean number of cells participating in a single SW were maintained. Therefore, dopaminergic activation is likely to reorganize cell assemblies during SWs.
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DOI：
10.1073/pnas.1103546108
发表时间：
2011-08-30
影响因子：
11.1
作者：
Baehner, Florian;Weiss, Elisa K.;Draguhn, Andreas
通讯作者：
Draguhn, Andreas
影响因子：
2.5
作者：
Ihalainen, JA;Riekkinen, P;Feenstra, MGP
通讯作者：
Feenstra, MGP
影响因子：
25
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
通讯作者：
Zugaro, Michael B.
影响因子：
5.3
作者：
Aivar, Paloma;Valero, Manuel;Menendez de la Prida, Liset
通讯作者：
Menendez de la Prida, Liset
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G