Information diversity in individual auditory cortical neurons is associated with functionally distinct coordinated neuronal ensembles.
Information diversity in individual auditory cortical neurons is associated with functionally distinct coordinated neuronal ensembles.
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DOI:
10.1038/s41598-021-83565-7
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发表时间:
2021-02-18
影响因子:
4.6
通讯作者:
Schreiner CE
中科院分区:
文献类型:
--
作者:
See JZ;Homma NY;Atencio CA;Sohal VS;Schreiner CE
Neuronal activity in auditory cortex is often highly synchronous between neighboring neurons. Such coordinated activity is thought to be crucial for information processing. We determined the functional properties of coordinated neuronal ensembles (cNEs) within primary auditory cortical (AI) columns relative to the contributing neurons. Nearly half of AI cNEs showed robust spectro-temporal receptive fields whereas the remaining cNEs showed little or no acoustic feature selectivity. cNEs can therefore capture either specific, time-locked information of spectro-temporal stimulus features or reflect stimulus-unspecific, less-time specific processing aspects. By contrast, we show that individual neurons can represent both of those aspects through membership in multiple cNEs with either high or absent feature selectivity. These associations produce functionally heterogeneous spikes identifiable by instantaneous association with different cNEs. This demonstrates that single neuron spike trains can sequentially convey multiple aspects that contribute to cortical processing, including stimulus-specific and unspecific information.
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