The Adult Phenylketonuria (PKU) Gut Microbiome.
The Adult Phenylketonuria (PKU) Gut Microbiome.
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DOI：
10.3390/microorganisms9030530
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发表时间：
2021-03-04
期刊：
影响因子：
4.5
通讯作者：
Allen MS
中科院分区：
文献类型：
--
作者：
Mancilla VJ;Mann AE;Zhang Y;Allen MS
Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism primarily treated through a phenylalanine-restrictive diet that is frequently supplemented with an amino acid formula to maintain proper nutrition. Little is known of the effects of these dietary interventions on the gut microbiome of PKU patients, particularly in adults. In this study, we sequenced the V4 region of the 16S rRNA gene from stool samples collected from adults with PKU (n = 11) and non-PKU controls (n = 21). Gut bacterial communities were characterized through measurements of diversity and taxa abundance. Additionally, metabolic imputation was performed based on detected bacteria. Gut community diversity was lower in PKU individuals, though this effect was only statistically suggestive. A total of 65 genera across 5 phyla were statistically differentially abundant between PKU and control samples (p < 0.001). Additionally, we identified six metabolic pathways that differed between groups (p < 0.05), with four enriched in PKU samples and two in controls. While the child PKU gut microbiome has been previously investigated, this is the first study to explore the gut microbiome of adult PKU patients. We find that microbial diversity in PKU children differs from PKU adults and highlights the need for further studies to understand the effects of dietary restrictions.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
4.2
作者：
Hemarajata, Peera;Versalovic, James
通讯作者：
Versalovic, James
DOI：
10.1097/dbp.0000000000000072
发表时间：
2014-07-01
影响因子：
2.4
作者：
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通讯作者：
McGill, Jim
影响因子：
3
作者：
Byers, HL;Homer, KA;Beighton, D
通讯作者：
Beighton, D
影响因子：
5.2
作者：
Breyner NM;Michon C;de Sousa CS;Vilas Boas PB;Chain F;Azevedo VA;Langella P;Chatel JM
通讯作者：
Chatel JM