Isolated hallucination is less predictive than thought disorder in psychosis: Insight from a longitudinal study in a clinical population at high risk for psychosis.
Isolated hallucination is less predictive than thought disorder in psychosis: Insight from a longitudinal study in a clinical population at high risk for psychosis.
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孤立的幻觉对精神病的预测能力不如思维障碍：对精神病高危人群的纵向研究的见解
DOI：
10.1038/s41598-018-32215-6
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发表时间：
2018-09-18
影响因子：
4.6
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhang T;Xu L;Tang Y;Cui H;Wei Y;Tang X;Hu Q;Wang Y;Zhu Y;Jiang L;Hui L;Liu X;Li C;Wang J
幻听等知觉异常(PA)是精神病患者最常见的症状之一。然而，目前尚不清楚亚临床PA的症状是否也在预测精神病方面发挥关键作用。在一项正在进行的前瞻性跟踪研究中，我们对精神病临床高危人群(CHR)进行了评估，评估了首次经历PAS和/或思维内容障碍(TCDs)预测精神病的可能性。转化为精神病是这项后续研究的主要焦点。共招募了511名CHR，其中443名(86.7%)完成了至少6个月至2年的临床随访。根据PAS和/或TCD的存在将CHR分为四组。在随访终点，39例(19.9%)单纯TCDs组、2例(8.3%)单纯PAS组、45例(17.0%)TCDs+PAS组和1例(3.8%)非PAS组的CHR转为精神病。生存分析显示，与单纯PAS组相比，TCDS组CHRS的中转率更高。与患有TCDs的患者相比，患有孤立PAS的CHRS患者在基线时表现出更高水平的焦虑不安情绪。约89%的TCDS含量与其经历过的PAS有关。与TCDs相比，孤立的PA与精神疾病的易感性增加没有很强的相关性。
Perceptual abnormalities (PAs) such as auditory hallucinations are one of the most common symptoms of psychotic patients. However, it remains unclear whether symptoms of sub-clinical PAs also play a key role in predicting psychosis. In an ongoing prospective follow-up study of individuals at a clinical high risk (CHR) of psychosis, we evaluated the potential of first-time experience of PAs and/or thought content disorders (TCDs) to predict psychosis. Conversion to psychosis was the major focus of this follow-up study. A total of 511 CHRs were recruited, of whom 443 (86.7%) completed the clinical follow-up of at least 6 months and up to 2 years. CHRs were divided into four groups according to the presence of PAs and/or TCDs. At the follow-up endpoint, 39 (19.9%) CHRs in the “TCDs-only” group, 2 (8.3%) in the “PAs-only” group, 45 (17.0%) in the “TCDs-and-PAs” group, and 1 (3.8%) in the “None” group converted to psychosis. Survival analysis revealed a higher conversion rate in CHRs with TCDs compared with those with PAs only. CHRs with isolated PAs had shown a higher level of dysphoric mood at baseline compared with those with TCDs. About 89% TCDs contents were related with their experienced PAs. Compared with TCDs, the isolated PAs are not strongly associated with increased susceptibility to psychosis.
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影响因子：
3.6
作者：
Schultze-Lutter, Frauke;Renner, Fritz;Ruhrmann, Stephan
通讯作者：
Ruhrmann, Stephan
精神病高风险状态：全面的最新评论。
影响因子：
25.8
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
通讯作者：
Yung, Alison
影响因子：
11.3
作者：
Ohayon, MM
通讯作者：
Ohayon, MM
影响因子：
8.1
作者：
Zhang, T. H.;Li, H. J.;Wang, J. J.
通讯作者：
Wang, J. J.
中国咨询中心人群的前驱精神病检测：一项流行病学和临床研究
影响因子：
4.5
作者：
Zhang T;Li H;Woodberry KA;Seidman LJ;Zheng L;Li H;Zhao S;Tang Y;Guo Q;Lu X;Zhuo K;Qian Z;Chow A;Li C;Jiang K;Xiao Z;Wang J
通讯作者：
Wang J