Impaired structural connectivity of socio-emotional circuits in autism spectrum disorders: a diffusion tensor imaging study.
Impaired structural connectivity of socio-emotional circuits in autism spectrum disorders: a diffusion tensor imaging study.
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DOI：
10.1371/journal.pone.0028044
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Anagnostou E
中科院分区：
文献类型：
--
作者：
Ameis SH;Fan J;Rockel C;Voineskos AN;Lobaugh NJ;Soorya L;Wang AT;Hollander E;Anagnostou E
白质发育异常可能会破坏神经回路内的整合，从而导致高阶行为的特定损伤。在自闭症谱系障碍 (ASD) 中，白质改变可能导致复杂的社会情感和沟通领域的特征缺陷。在这里，我们使用扩散张量成像 (DTI) 和基于束的空间统计 (TBSS) 来评估 ASD 中的白质微观结构。在 3T MRI 系统上对 19 名患有自闭症谱系障碍 (ASD) 的儿童和青少年（~8-18 岁；平均 12.4±3.1）和 16 名年龄和智商匹配的对照者（~8-18 岁；平均 12.3±3.6）进行了 DTI 扫描。测量了分数各向异性、平均扩散率、径向扩散率和轴向扩散率的 DTI 值。检查了整体和体素白质指数的年龄组相互作用。对 ASD 与对照进行体素分析：（i）完整队列（ii）仅儿童（≤12 岁）和（iii）仅青少年（>12 岁），然后进行特定区域的比较。所有三种扩散率指标均发现全球 DTI 指数存在显着的年龄组交互作用，但分数各向异性则不然。体素分析显示，与健康对照相比，自闭症谱系障碍儿童（而非青少年）存在显着的扩散测量差异。自闭症儿童的平均和径向扩散率普遍增加，在额叶白质体素中尤为突出。后续的特定区域分析强调了参与社会情绪处理的额叶、颞叶和枕骨结构整合路径的破坏。我们的研究结果强调了自闭症谱系障碍中神经回路的破坏，特别是在那些整合了在这种疾病中受损的复杂社会情感处理的白质束中。
Abnormal white matter development may disrupt integration within neural circuits, causing particular impairments in higher-order behaviours. In autism spectrum disorders (ASDs), white matter alterations may contribute to characteristic deficits in complex socio-emotional and communication domains. Here, we used diffusion tensor imaging (DTI) and tract based spatial statistics (TBSS) to evaluate white matter microstructure in ASD. DTI scans were acquired for 19 children and adolescents with ASD (∼8–18 years; mean 12.4±3.1) and 16 age and IQ matched controls (∼8–18 years; mean 12.3±3.6) on a 3T MRI system. DTI values for fractional anisotropy, mean diffusivity, radial diffusivity and axial diffusivity, were measured. Age by group interactions for global and voxel-wise white matter indices were examined. Voxel-wise analyses comparing ASD with controls in: (i) the full cohort (ii), children only (≤12 yrs.), and (iii) adolescents only (>12 yrs.) were performed, followed by tract-specific comparisons. Significant age-by-group interactions on global DTI indices were found for all three diffusivity measures, but not for fractional anisotropy. Voxel-wise analyses revealed prominent diffusion measure differences in ASD children but not adolescents, when compared to healthy controls. Widespread increases in mean and radial diffusivity in ASD children were prominent in frontal white matter voxels. Follow-up tract-specific analyses highlighted disruption to pathways integrating frontal, temporal, and occipital structures involved in socio-emotional processing. Our findings highlight disruption of neural circuitry in ASD, particularly in those white matter tracts that integrate the complex socio-emotional processing that is impaired in this disorder.
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影响因子：
5.7
作者：
Carper, RA;Moses, P;Courchesne, E
通讯作者：
Courchesne, E
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1111/j.1469-7610.2009.02086.x
发表时间：
2009-09-01
影响因子：
7.6
作者：
Cheung, C.;Chua, S. E.;McAlonan, G. M.
通讯作者：
McAlonan, G. M.
影响因子：
5.7
作者：
Cheng, Yawei;Chou, Kun-Hsien;Lin, Ching-Po
通讯作者：
Lin, Ching-Po