Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study.
Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study.
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DOI：
10.3899/jrheum.080646
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Neogi T;Ellison RC;Hunt S;Terkeltaub R;Felson DT;Zhang Y
研究血尿酸(SUA)与临床前心血管疾病(CVD)的标志物颈动脉粥样硬化斑块(PLQ)的相关性，重点关注没有心血管危险因素的个体。国家心肺血液研究所家庭心脏研究是一项旨在评估心脏病风险因素的多中心研究。用颈动脉超声检测PLQ。我们进行了性别相关的Logistic回归分析，以评估血尿酸与PLQ的相关性，包括对没有心血管疾病和高尿酸血症危险因素的人群进行分析。总共有4866名参与者同时接受了SUA和颈动脉超声检查(54%的女性，平均年龄52岁，平均体重指数27.6)。男性血尿酸与PLQ的相关性随着血尿酸水平的增加而增加，表现出剂量-反应关系[分别为：尿酸类别5(参考)，5，6，6，6.8，≥6.8 mg/dl；p=0.002]。在没有心血管风险因素的男性中也发现了类似的关联。我们在女性中未发现血尿酸与PLQ的关系。在这项大型研究中，男性的颈动脉粥样硬化斑块与血尿酸有关。在没有心血管危险因素的情况下，结果是相似的。这些结果提示，血尿酸可能在男性动脉粥样硬化中起着病理生理作用。(J Rheumatol首次发布，2008年11月15日；DOI：10.3899/jhurum.080646)
To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound. We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. (J Rheumatol First Release Nov 15 2008; doi:10.3899/jrheum.080646)
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影响因子：
3.2
作者：
Cuspidi, Cesare;Valerio, Cristiana;Mancia, Giuseppe
通讯作者：
Mancia, Giuseppe
影响因子：
5
作者：
BRAND, FN;MCGEE, DL;CASTELLI, WP
通讯作者：
CASTELLI, WP
影响因子：
3
作者：
BOND, MG;PURVIS, C;MERCURI, M
通讯作者：
MERCURI, M
影响因子：
8.3
作者：
Bos, Michiel J.;Koudstaal, Peter J.;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
影响因子：
120.7
作者：
Fang, J;Alderman, MH
通讯作者：
Alderman, MH