Habitual flavonoid intake and endothelial function in healthy humans.
Habitual flavonoid intake and endothelial function in healthy humans.
复制标题
DOI：
10.1080/07315724.2012.10720433
复制
发表时间：
2012-08
影响因子：
3.5
通讯作者：
Hollenberg NK
中科院分区：
文献类型：
--
作者：
Fisher ND;Hurwitz S;Hollenberg NK
已知通过非侵入性技术测量的内皮功能在人群中差异很大。我们的研究旨在验证这一假设，即这种变化在很大程度上是由一个人的习惯性膳食摄入类黄酮决定的。这是一项分析性研究，研究了19名健康老年人（平均年龄72岁）的内皮功能和膳食黄酮之间的关系。这项研究在布莱根妇女医院的住院临床研究中心进行。习惯性黄酮类化合物的摄入量通过集中的食物频率问卷进行评估。内皮功能，测量为反应性充血反应的一个剂量的富含类黄酮的可可，记录与体积描记装置通过外周动脉张力计（PAT）。背景类黄酮摄入量和反应性充血（RH）-PAT反应显着相关（r=0.7，p=0.001）;高习惯性类黄酮摄入量的受试者表现出显着更大的RH-PAT反应比低消费者。PAT对可可的反应也与血液中的黄烷醇浓度显著相关（r=0.5，p=0.03）。健康老年人内皮功能的个体差异，以PAT对富含类黄酮的可可的反应来衡量，高度依赖于日常类黄酮的摄入量。这些数据提高了水果和蔬菜的消费决定基础内皮功能的可能性，可能与其类黄酮含量和对一氧化氮的影响有关。
Endothelial function, as measured by non-invasive techniques, is known to vary widely within populations. Our study was designed to test the hypothesis that this variation is determined in large part by a person’s habitual dietary intake of flavonoids. This was an analytical study examining the relationship between endothelial function and dietary flavonoids in 19 healthy older adults (mean age 72 years). The study took place in the inpatient Clinical Research Center of the Brigham and Women’s Hospital. Habitual flavonoid intake was assessed via a focused food frequency questionnaire. Endothelial function, measured as the reactive hyperemia response to one dose of flavonoid-rich cocoa, was recorded with a plethysmograpic device via peripheral arterial tonometry (PAT). Background flavonoid intake and the reactive hyperemia (RH)-PAT response were significantly correlated (r=0.7, p=0.001); subjects with higher habitual flavonoid intake showed a significantly greater RH-PAT response than did lower consumers. PAT response to cocoa was also significantly correlated with simultaneous flavanol concentration in the blood (r=0.5, p=0.03). Individual variation in endothelial function among healthy older people, measured as PAT response to flavonoid-rich cocoa, is highly dependent upon usual daily flavonoid consumption. These data raise the possibility that the consumption of fruits and vegetables dictates basal endothelial function, likely related to their flavonoid content and influence on nitric oxide.
登录
查看更多内容
影响因子：
37.8
作者：
Leikert, JF;Räthel, TR;Dirsch, VM
通讯作者：
Dirsch, VM
影响因子：
37.8
作者：
Mukamal, KJ;Maclure, M;Mittleman, MA
通讯作者：
Mittleman, MA
影响因子：
4.9
作者：
Fisher, NDL;Hughes, M;Hollenberg, NK
通讯作者：
Hollenberg, NK
影响因子：
8.3
作者：
Diebolt, M;Bucher, B;Andriantsitohaina, R
通讯作者：
Andriantsitohaina, R
影响因子：
7.1
作者：
Geleijnse, JM;Launer, LJ;Witteman, JCM
通讯作者：
Witteman, JCM