Elevation in fibroblast growth factor 23 and its value for identifying subclinical atherosclerosis in first-degree relatives of patients with diabetes.
Elevation in fibroblast growth factor 23 and its value for identifying subclinical atherosclerosis in first-degree relatives of patients with diabetes.
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DOI：
10.1038/srep34696
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发表时间：
2016-10-04
影响因子：
4.6
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Hu X;Ma X;Luo Y;Xu Y;Xiong Q;Pan X;Bao Y;Jia W
越来越多的证据支持糖尿病与成纤维细胞生长因子23(FGF23)之间的联系。本研究的目的是探索血清FGF23水平的变化，并评估其在具有一级糖尿病家族史(FHD)的正常血糖个体中识别亚临床动脉粥样硬化的价值。这项研究招募了312名有一级FHD学位的受试者和1407名没有FHD学位的受试者。采用夹心酶联免疫吸附试验检测血清FGF23水平。血清FGF23水平在有一度先天性心脏病的受试者中显著高于未患先天性心脏病的受试者(P = 0.006)。一级FHD与血清FGF23水平呈正相关，与C-IMT和心血管因素无关(P <； 0.05)。在有一级FHD的受试者中，只有那些血清FGF23水平在上四分之一的人更有可能有C-IMT增加(优势比 = 2.263，P <； 0.05)。作为结论，一级FHD独立地促进了血清FGF23水平的升高。患有一级FHD的受试者需要较高的血清FGF23水平来提示亚临床动脉粥样硬化。应该考虑一级FHD对血清FGF23水平的影响，以避免高估患有一级FHD的血糖正常的个体发生心血管疾病的风险。
Accumulating evidence supported an association between diabetes and fibroblast growth factor 23 (FGF23). The goal of the present study was to explore alteration in serum FGF23 levels and to assess its value for identifying subclinical atherosclerosis in normoglycemic individuals with a first-degree family history of diabetes (FHD). The study enrolled 312 subjects with a first-degree FHD and 1407 subjects without an FHD. Serum FGF23 levels were detected by a sandwich enzyme-linked immunosorbent assay. Serum FGF23 levels were much higher in subjects with a first-degree FHD than in those without an FHD (P = 0.006). A first-degree FHD was positively associated with serum FGF23 levels, independent of C-IMT and cardiovascular factors (both P < 0.05). In subjects with a first-degree FHD, only those with serum FGF23 levels in the upper quartile were more likely to have an increased C-IMT (odds ratio = 2.263, P < 0.05). As conclusions, a first-degree FHD contributes to the increased serum FGF23 levels independently. Subjects with a first-degree FHD need higher serum FGF23 levels to indicate subclinical atherosclerosis. The influence of a first-degree FHD on serum FGF23 levels should be considered to avoid overestimating the risk of cardiovascular disease in normoglycemic individuals with a first-degree FHD.
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作者：
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通讯作者：
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