Alcohol Use and the Risk of Colorectal Liver Metastasis: A Systematic Mapping Review.
Alcohol Use and the Risk of Colorectal Liver Metastasis: A Systematic Mapping Review.
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结直肠癌（CRC）是全球第三大诊断癌症，也是美国第二大死亡原因。许多与CRC相关的死亡是由于结肠肿瘤转移到肝脏。饮酒与肝脏疾病和结肠癌风险增加有关。然而，目前尚不清楚饮酒和相关的肝损伤是否与CRC患者的肝转移和预后不良有关。本研究的目的是对文献进行系统的映射综述，以确定调查酒精使用和结直肠肝转移（CRLM）风险的研究中的差距。该综述确定了过去十年中的14篇出版物，这些出版物评估了酒精使用，CRLM的风险以及促进酒精损伤肝脏转移的相关机制。确定的研究数量表明，目前的研究重点有限，评估转移性疾病中饮酒的后果和CRC患者的健康。总体而言，这一研究领域存在重大差距，表明需要更好地了解与酒精使用和CRC结局相关的全球主要医疗保健问题。长期以来，酒精的消费与肝脏疾病以及包括结直肠癌（CRC）在内的癌症的发展有关。主要的医疗保健问题包括酒精的普遍使用和CRC死亡率的高负担。许多CRC死亡归因于结直肠肝转移（CRLM）的发展，因为肝脏是CRC扩散的最主要部位。然而，尚未确定酒精摄入和相关肝损伤与CRLM发展的关系。在这里，对最近的研究进行了映射审查，以评估饮酒与CRLM风险之间的关系。文献检索显示14篇文章符合纳入标准，包括患者数据库分析和临床前研究。大多数人类数据分析发现，饮酒与CRC预后不良独立相关。临床前评价确定了酒精介导的促进CRLM负荷和CRC细胞转移行为的几种途径。确定的研究数量有限，这表明需要进行更多的前瞻性分析，以确定酒精摄入和晚期CRC的作用，以及临床前研究的转化，以充分表征产生新治疗选择的靶向机制。
Colorectal cancer (CRC) is the third most diagnosed cancer worldwide and the second leading cause of death in the United States. Many deaths associated with CRC are due to the metastatic spread of colon tumors to the liver. Drinking alcohol has been associated with liver diseases and an increased risk of developing colon cancer. However, it is not understood whether alcohol consumption and related liver damage associates with liver metastasis and worse outcomes in CRC patients. The objective of this study was to conduct a systematic mapping review of the literature to identify gaps in research investigating alcohol use and the risk of colorectal liver metastasis (CRLM). The review identified 14 publications in the last decade that evaluated alcohol use, the risk of CRLM, and contributing mechanisms involved in promoting metastasis in the alcohol-injured liver. The number of studies identified demonstrates the limited focus in current research evaluating the consequences of alcohol consumption in metastatic disease and the health of CRC patients. Overall, significant gaps in this area of research have been identified demonstrating the need for a better understanding of major worldwide healthcare issues related to alcohol use and CRC outcomes. The consumption of alcohol has long been associated with the development of liver disease as well as cancers including colorectal cancer (CRC). Leading healthcare concerns include the prevalent use of alcohol and the high burden of CRC mortality. Many CRC deaths are attributed to the development of colorectal liver metastasis (CRLM) as the liver is the foremost site of CRC spread. However, an association has not been defined for the role of alcohol intake and related liver injury with the development of CRLM. Here, a mapping review of recent research was undertaken to evaluate the relationship between alcohol consumption and the risk of CRLM. The literature search revealed 14 articles meeting the inclusion criteria that included patient database analyses and preclinical studies. Most of the human data analyses found alcohol use independently associates with worse CRC outcomes. The preclinical evaluations identified several pathways involved in the alcohol-mediated promotion of CRLM burden and CRC cell metastatic behavior. The limited number of studies identified exposes a significant need for more prospective analyses to define the role of alcohol intake and advanced CRC as well as the translation of preclinical research to fully characterize targetable mechanisms for the generation of new therapeutic options.
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影响因子：
4.6
作者：
Hudson, Shanice V.;Miller, Hunter A.;Frieboes, Hermann B.
通讯作者：
Frieboes, Hermann B.
影响因子：
13.5
作者：
Julien, Jovan;Ayer, Turgay;Chhatwal, Jagpreet
通讯作者：
Chhatwal, Jagpreet
影响因子：
2.8
作者：
Northcote, Jeremy;Livingston, Michael
通讯作者：
Livingston, Michael
影响因子：
6.2
作者：
Pelser, Colleen;Arem, Hannah;Pfeiffer, Ruth M.;Elena, Joanne W.;Alfano, Catherine M.;Hollenbeck, Albert R.;Park, Yikyung
通讯作者：
Park, Yikyung
影响因子：
6.4
作者：
McNabb, Sarah;Harrison, Tabitha A.;Peters, Ulrike
通讯作者：
Peters, Ulrike