Prediagnostic lifestyle factors and survival after colon and rectal cancer diagnosis in the National Institutes of Health (NIH)-AARP Diet and Health Study.
Prediagnostic lifestyle factors and survival after colon and rectal cancer diagnosis in the National Institutes of Health (NIH)-AARP Diet and Health Study.
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DOI：
10.1002/cncr.28573
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发表时间：
2014-05-15
期刊：
影响因子：
6.2
通讯作者：
Park, Yikyung
中科院分区：
文献类型：
--
作者：
Pelser, Colleen;Arem, Hannah;Pfeiffer, Ruth M.;Elena, Joanne W.;Alfano, Catherine M.;Hollenbeck, Albert R.;Park, Yikyung
很少有研究考察生活方式因素与结直肠癌患者死亡率的关系。在美国国立卫生研究院-美国退休人员协会饮食与健康研究的参与者中，我们通过与州癌症登记处的联系确定了4213例结肠癌和1514例直肠癌病例，并使用国家死亡指数确定了死亡日期和原因。生活方式因素在基线时进行了评估，包括：健康饮食（由2005年健康饮食指数（HEI-2005）衡量）、体重指数（BMI）、体育活动、饮酒和吸烟。我们单独检查了这些因素的相关性，并将其与生活方式评分与全因死亡率、结直肠癌和心血管疾病（CVD）的5年死亡率相结合。我们使用Cox比例风险模型估计相对风险（RRs）和95%置信区间（CIs）。在结肠癌幸存者中，与从不吸烟者相比，吸烟者总死亡率（RR 1.74; 95% CI 1.45-2.08）和结直肠癌死亡率（1.46;1.17-1.82）的风险更高。与正常体重（BMI 18.5至<25）的个体相比，肥胖（BMI≥30）个体的所有死亡风险（1.19;1.02-1.39）和心血管疾病死亡风险（1.84;1.05-3.23）均增加。与生活方式得分最低的人相比，得分最高的人全因死亡风险降低34%（0.66;0.50-0.87）。在直肠癌幸存者中，HEI-2005得分最高的五分之一个体的全因死亡率（0.60;0.42-0.86）比得分最低的五分之一个体低。较高的综合生活方式评分与总死亡风险降低46%相关（0.54;0.32-0.91）。癌症诊断前更健康的生活方式与结直肠癌诊断后总生存率的提高相关。
Few studies have examined the relationship of lifestyle factors with mortality among colorectal cancer patients. Among NIH-AARP Diet and Health study participants we identified 4,213 colon and 1,514 rectal cancer cases through linkage to state cancer registries and determined date and cause of death using the National Death Index. Lifestyle factors were assessed at baseline and included: healthy diet (measured by Healthy Eating Index 2005; HEI-2005), body mass index (BMI), physical activity, alcohol consumption and smoking. We examined the association of factors individually and combined into a lifestyle score with five-year mortality from all-causes, colorectal cancer, and cardiovascular disease (CVD). We estimated relative risks (RRs) and 95% confidence intervals (CIs) using Cox proportional hazards models. Among colon cancer survivors, smokers had increased risk of total mortality (RR 1.74; 95% CI 1.45–2.08) and colorectal cancer mortality (1.46; 1.17–1.82), compared to never smokers. Obese (BMI ≥30) individuals had increased risk of all death (1.19; 1.02–1.39) and CVD death (1.84; 1.05–3.23), compared to normal weight (BMI 18.5 to <25) individuals. Compared to those with the lowest lifestyle score, those with the highest score had a 34% lower risk of all-cause mortality (0.66; 0.50–0.87). Among rectal cancer survivors, individuals in the highest quintile of HEI-2005 scores had reduced all-cause mortality (0.60; 0.42–0.86) compared to those in the lowest. Higher combined lifestyle scores were associated with a 46% lower risk of total mortality (0.54; 0.32–0.91). Healthier lifestyle before cancer diagnosis was associated with improved overall survival after diagnosis with colorectal cancer.
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影响因子：
6.2
作者：
Phipps AI;Baron J;Newcomb PA
通讯作者：
Newcomb PA
影响因子：
45.3
作者：
Campbell, Peter T.;Patel, Alpa V.;Gapstur, Susan M.
通讯作者：
Gapstur, Susan M.
影响因子：
45.3
作者：
Campbell, Peter T.;Newton, Christina C.;Gapstur, Susan M.
通讯作者：
Gapstur, Susan M.
影响因子：
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作者：
Meyerhardt, Jeffrey A.;Giovannucci, Edward L.;Fuchs, Charles S.
通讯作者：
Fuchs, Charles S.
影响因子：
254.7
作者：
Rock, Cheryl L.;Doyle, Colleen;Gansler, Ted
通讯作者：
Gansler, Ted