Ionic current correlations are ubiquitous across phyla
Ionic current correlations are ubiquitous across phyla
复制标题
离子电流相关性在整个门中普遍存在
DOI：
10.1038/s41598-018-38405-6
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发表时间：
2019
影响因子：
4.6
通讯作者：
Golowasch, Jorge
中科院分区：
文献类型：
--
作者：
Tran, Trinh;Unal, Cagri T.;Severin, Daniel;Zaborszky, Laszlo;Rotstein, Horacio G.;Kirkwood, Alfredo;Golowasch, Jorge
离子电流，无论是测量电导振幅还是离子通道转录数，都可以在已识别的神经元群体中变化许多倍。在无脊椎动物神经元类型中，可以看到多个电流在变化，同时它们的大小是相关的。这些电导振幅相关性被认为反映了细胞兴奋性的紧密内稳态，增强了神经元活动在长时间内的稳健性和稳定性。虽然这种离子电导相关性在无脊椎动物中有很好的记录，但在脊椎动物中尚未报道。在这里，我们通过两个例子，鉴定小鼠海马颗粒细胞（GCs）和胆碱能基底前脑神经元，证明了不同离子电流之间的离子电导振幅的相关性也存在于脊椎动物中，我们认为这是一种普遍存在的现象，许多物种跨门表达。我们进一步证明，在齿状回GCs中，这些电导相关性可能以昼夜节律方式调节。这让人想起甲壳类动物中已知的神经调节剂对电导的调节。然而，在gc中，我们观察到一种更细微的调节，其中对于某些电导对，相关性完全消除，而对于其他电导对，相关性被定量修改，但没有被消除。
Ionic currents, whether measured as conductance amplitude or as ion channel transcript numbers, can vary many-fold within a population of identified neurons. In invertebrate neuronal types multiple currents can be seen to vary while at the same time their magnitudes are correlated. These conductance amplitude correlations are thought to reflect a tight homeostasis of cellular excitability that enhances the robustness and stability of neuronal activity over long stretches of time. Although such ionic conductance correlations are well documented in invertebrates, they have not been reported in vertebrates. Here we demonstrate with two examples, identified mouse hippocampal granule cells (GCs) and cholinergic basal forebrain neurons, that the correlation of ionic conductance amplitudes between different ionic currents also exists in vertebrates, and we argue that it is a ubiquitous phenomenon expressed by many species across phyla. We further demonstrate that in dentate gyrus GCs these conductance correlations are likely regulated in a circadian manner. This is reminiscent of the known conductance regulation by neuromodulators in crustaceans. However, in GCs we observe a more nuanced regulation, where for some conductance pairs the correlations are completely eliminated while for others the correlation is quantitatively modified but not obliterated.
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影响因子：
5.3
作者：
Ransdell, Joseph L.;Nair, Satish S.;Schulz, David J.
通讯作者：
Schulz, David J.
影响因子：
5.3
作者：
Goldman, MS;Golowasch, J;Abbott, LF
通讯作者：
Abbott, LF
DOI：
10.1073/pnas.1309966110
发表时间：
2013-07-09
影响因子：
11.1
作者：
O'Leary, Timothy;Williams, Alex H.;Marder, Eve
通讯作者：
Marder, Eve
具有由多个钙传感器调节的活动依赖性电导的模型神经元。
DOI：
10.1523/jneurosci.18-07-02309.1998
发表时间：
1998
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liu,Z;Golowasch,J;Marder,E;Abbott,LF
通讯作者：
Abbott,LF
影响因子：
25
作者：
Schulz, DJ;Goaillard, JM;Marder, E
通讯作者：
Marder, E