Cellular Carcinogenesis: Role of Polarized Macrophages in Cancer Initiation.
Cellular Carcinogenesis: Role of Polarized Macrophages in Cancer Initiation.
复制标题
细胞癌变：极化巨噬细胞在癌症发生中的作用
作者：
炎症是许多癌症的标志。巨噬细胞是先天免疫的关键参与者和炎症的重要驱动因素。当长期极化超出对感染、损伤或衰老的正常稳态反应时，巨噬细胞可以表达几种促致癌表型。在这篇综述中，证据支持极化巨噬细胞作为内源性致癌源进行了讨论。此外，通过小分子抑制剂和益生菌消耗或调节巨噬细胞被认为是癌症预防的新兴策略。炎症是癌症的一个重要标志。巨噬细胞是慢性炎症、副炎症和炎症中关键的先天性免疫效应细胞。副炎症是一种与持续DNA损伤反应相关的亚临床炎症。炎症代表由于随着衰老发生的先天性和适应性免疫应答的失调而引起的低度炎症。无论是由感染、损伤还是衰老诱导，免疫失调和慢性巨噬细胞极化都通过产生促炎趋化因子/细胞因子和基因毒素以及通过调节免疫监视而促成癌症的发生。本文综述了极化巨噬细胞作为内源性细胞致癌物在慢性炎症、副炎症和炎症中的临床前和临床证据。针对巨噬细胞功能和表型的癌症预防新策略，包括小分子抑制剂和益生菌方法也进行了讨论。
Inflammation is a hallmark of many cancers. Macrophages are key participants in innate immunity and important drivers of inflammation. When chronically polarized beyond normal homeostatic responses to infection, injury, or aging, macrophages can express several pro-carcinogenic phenotypes. In this review, evidence supporting polarized macrophages as endogenous sources of carcinogenesis is discussed. In addition, the depletion or modulation of macrophages by small molecule inhibitors and probiotics are reviewed as emerging strategies in cancer prevention. Inflammation is an essential hallmark of cancer. Macrophages are key innate immune effector cells in chronic inflammation, parainflammation, and inflammaging. Parainflammation is a form of subclinical inflammation associated with a persistent DNA damage response. Inflammaging represents low-grade inflammation due to the dysregulation of innate and adaptive immune responses that occur with aging. Whether induced by infection, injury, or aging, immune dysregulation and chronic macrophage polarization contributes to cancer initiation through the production of proinflammatory chemokines/cytokines and genotoxins and by modulating immune surveillance. This review presents pre-clinical and clinical evidence for polarized macrophages as endogenous cellular carcinogens in the context of chronic inflammation, parainflammation, and inflammaging. Emerging strategies for cancer prevention, including small molecule inhibitors and probiotic approaches, that target macrophage function and phenotype are also discussed.
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影响因子：
7.7
作者：
Chia K;Mazzolini J;Mione M;Sieger D
通讯作者：
Sieger D
DOI：
10.1084/jem.20090896
发表时间：
2009-08-31
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Agius E;Lacy KE;Vukmanovic-Stejic M;Jagger AL;Papageorgiou AP;Hall S;Reed JR;Curnow SJ;Fuentes-Duculan J;Buckley CD;Salmon M;Taams LS;Krueger J;Greenwood J;Klein N;Rustin MH;Akbar AN
通讯作者：
Akbar AN
影响因子：
4.3
作者：
Burclaff J;Mills JC
通讯作者：
Mills JC
影响因子：
3.4
作者：
Burr, Karen L.;Robinson, Joanne T.;Wright, Eric G.
通讯作者：
Wright, Eric G.
影响因子：
4.6
作者：
Aprahamian, T.;Takemura, Y.;Walsh, K.
通讯作者：
Walsh, K.