Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia.
Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia.
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DOI：
10.1016/j.neuron.2011.12.024
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发表时间：
2012-02-23
期刊：
影响因子：
16.2
通讯作者：
Vinogradov S
中科院分区：
文献类型：
--
作者：
Subramaniam K;Luks TL;Fisher M;Simpson GV;Nagarajan S;Vinogradov S
精神分裂症患者患有严重的认知缺陷，例如现实监控受损。现实监控是区分内部经验来源与外部现实的能力。在现实监控任务中，精神分裂症患者会错误地识别“我编造的”项目，即使在准确执行的过程中，他们也会表现出内侧前额叶皮层（mPFC）的异常低激活，该区域支持自我参照认知。我们对精神分裂症患者进行了 80 小时的计算机化认知过程训练，发现现实监测的改善与 mPFC 活动的增加相关。相比之下，处于电脑游戏控制条件下的患者没有表现出任何行为或神经改善。值得注意的是，训练后 mPFC 活动的恢复与六个月后社会功能的改善相关。这些发现表明，精神分裂症的严重行为缺陷及其潜在的神经功能障碍可以通过精心设计的计算机认知训练得到改善，从而提高生活质量。
Schizophrenia patients suffer from severe cognitive deficits, such as impaired reality monitoring. Reality monitoring is the ability to distinguish the source of internal experiences from outside reality. During reality monitoring tasks, schizophrenia patients make errors identifying “I made it up” items, and even during accurate performance, they show abnormally low activation of the medial prefrontal cortex (mPFC), a region that supports self-referential cognition. We administered 80 hours of computerized training of cognitive processes to schizophrenia patients and found improvement in reality monitoring that correlated with increased mPFC activity. In contrast, patients in a computer games control condition did not show any behavioral or neural improvements. Notably, recovery in mPFC activity after training was associated with improved social functioning six months later. These findings demonstrate that a serious behavioral deficit in schizophrenia, and its underlying neural dysfunction, can be improved by well-designed computerized cognitive training, resulting in better quality of life.
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