Chromium VI - Induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins.
Chromium VI - Induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins.
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DOI：
10.1016/j.reprotox.2016.07.006
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Burghardt RC
中科院分区：
文献类型：
--
作者：
Banu SK;Stanley JA;Sivakumar KK;Arosh JA;Taylor RJ;Burghardt RC
六价铬（CrVI）的环境污染在美国和发展中国家都是一个日益严重的问题。六价铬是一种重金属内分泌干扰物;在铬行业工作的妇女过早流产和不孕症的发生率增加。本研究旨在了解CrVI毒性对胎盘细胞存活/死亡途径的机制。从妊娠第9.5-14.5天（GD）开始，通过饮用水对妊娠母亲进行CrVI（50 ppm K2 Cr2 O 7）或不进行CrVI（50 ppm K2 Cr2 O 7）处理，并在GD 18.5分析胎盘。结果表明，CrVI通过caspase-3和p53依赖的途径促进滋养层细胞、子宫腺血管内皮细胞和卵黄囊上皮细胞的凋亡。CrVI通过AIF和ATM-p53-NOXA-p27网络以caspase-3非依赖性方式增加迷路和基底区的凋亡。CrVI下调胎盘中的细胞存活蛋白Bcl-2、Bcl-XL和XIAP。CrVI破坏胎盘组织结构，并通过时空调节凋亡信号增加细胞死亡。
Environmental contamination with hexavalent chromium (CrVI) is a growing problem both in the U.S and developing countries. CrVI is a heavy-metal endocrine disruptor; women working in Cr industries exhibit an increased incidence of premature abortion and infertility. The current study was designed to understand the mechanism of CrVI toxicity on placental cell survival/death pathways. Pregnant mothers were treated with or without CrVI (50 ppm K2Cr2O7) through drinking water from gestational day (GD) 9.5–14.5, and placentas were analyzed on GD 18.5. Results indicated that CrVI increased apoptosis of trophoblasts, vascular endothelium of the metrial glands and yolk sac epithelium through caspase-3 and p53-dependent pathways. CrVI increased apoptosis in labyrinth and basal zones in a caspase-3-independent manner via AIF, and through an ATM-p53-NOXA-PUMA-p27 network. CrVI downregulated cell survival proteins Bcl-2, Bcl-XL and XIAP in the placenta. CrVI disrupts placental histoarchitecture and increases cell death by spatiotemporal modulation of apoptotic signaling.
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影响因子：
4.1
作者：
Bauer, MK;Harding, JE;Gluckman, PD
通讯作者：
Gluckman, PD
影响因子：
3.6
作者：
BRUCE, NW
通讯作者：
BRUCE, NW
影响因子：
1.5
作者：
de Rijk, EPCT;van Esch, E;Flik, G
通讯作者：
Flik, G
影响因子：
3.6
作者：
Banu, Sakhila K.;Stanley, Jone A.;Burghardt, Robert C.
通讯作者：
Burghardt, Robert C.
影响因子：
10.4
作者：
ARMIENTAHERNANDEZ, MA;RODRIGUEZCASTILLO, R
通讯作者：
RODRIGUEZCASTILLO, R