Dissociable brain signatures of choice conflict and immediate reward preferences in alcohol use disorders.
Dissociable brain signatures of choice conflict and immediate reward preferences in alcohol use disorders.
复制标题
DOI：
10.1111/adb.12017
复制
发表时间：
2014-07
影响因子：
3.4
通讯作者：
MacKillop J
中科院分区：
文献类型：
--
作者：
Amlung M;Sweet LH;Acker J;Brown CL;MacKillop J
冲动性延迟奖励折扣（DRD）是酒精使用障碍（AUD）中的一个重要行为过程，反映了延迟满足的能力。神经经济学的最新研究已经开始揭示支持DRD的神经机制，但神经经济学在AUD方面的应用受到限制。本研究探讨了AUD中DRD偏好的神经机制，重点是基于DRD选择类型和认知冲突水平的解离激活模式。重度饮酒的成年男性（n = 13）和没有（n = 12）诊断的AUD完成了货币DRD任务在功能性磁共振成像扫描。参与者的反应是根据选择类型（冲动与克制）和认知冲突的水平（容易与困难）进行编码的。AUD+参与者表现出明显更冲动的DRD决策。在DRD过程中，在几个决策区域发现了显着的激活，包括背外侧前额叶皮层（DLPFC），后额叶皮层（PPC），后扣带回。还观察到一个认知冲突的轴，与前扣带皮层和容易的选择与辅助运动区激活相关的硬选择。AUD+个体在与认知控制（DLPFC）和前瞻性思维（PPC）相关的区域表现出显著的过度活跃，并且在DRD决策期间与大脑默认网络相关的区域表现出较少的任务相关失活。这项研究进一步阐明了支持DRD的大脑系统以及与AUD的关系。
Impulsive delayed reward discounting (DRD) is an important behavioral process in alcohol use disorders (AUDs), reflecting incapacity to delay gratification. Recent work in neuroeconomics has begun to unravel the neural mechanisms supporting DRD, but applications of neuroeconomics in relation to AUDs have been limited. This study examined the neural mechanisms of DRD preferences in AUDs, with emphasis on dissociating activation patterns based on DRD choice type and level of cognitive conflict. Heavy drinking adult males with (n = 13) and without (n = 12) a diagnosis of an AUD completed a monetary DRD task during a functional magnetic resonance imaging scan. Participant responses were coded based on choice type (impulsive vs. restrained) and level of cognitive conflict (easy vs. hard). AUD+ participants exhibited significantly more impulsive DRD decision-making. Significant activation during DRD was found in several decision-making regions, including dorsolateral prefrontal cortex (DLPFC), insula, posterior parietal cortex (PPC), and posterior cingulate. An axis of cognitive conflict was also observed, with hard choices associated with anterior cingulate cortex and easy choices associated with activation in supplementary motor area. AUD+ individuals exhibited significant hyperactivity in regions associated with cognitive control (DLPFC) and prospective thought (PPC) and exhibited less task-related deactivation of areas associated with the brain's default network during DRD decisions. This study provides further clarification of the brain systems supporting DRD in general and in relation to AUDs.
登录
查看更多内容
影响因子：
3.6
作者：
Boettiger, Charlotte A.;Kelley, Elizabeth A.;Mitchell, Jennifer M.;D'Esposito, Mark;Fields, Howard L.
通讯作者：
Fields, Howard L.
影响因子：
5.7
作者：
Ballard K;Knutson B
通讯作者：
Knutson B
影响因子：
3.4
作者：
Bickel, Warren K.;Jarmolowicz, David P.;Mueller, E. Terry;Gatchalian, Kirstin M.;McClure, Samuel M.
通讯作者：
McClure, Samuel M.
影响因子：
5.7
作者：
Cohen, MS
通讯作者：
Cohen, MS
影响因子：
25
作者：
Kable, Joseph W.;Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.