Slower immune system aging in women versus men in the Japanese population.
Slower immune system aging in women versus men in the Japanese population.
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DOI：
10.1186/1742-4933-10-19
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发表时间：
2013-05-15
期刊：
影响因子：
--
通讯作者：
Fulop T
中科院分区：
文献类型：
--
作者：
Hirokawa K;Utsuyama M;Hayashi Y;Kitagawa M;Makinodan T;Fulop T
与性别有关的人类差异通常在行为、身体活动、疾病和寿命方面观察到。然而，与年龄相关的免疫系统变化在男性和女性之间存在差异的观点仍然存在争议。为了阐明免疫变化与寿命之间的关系，用三色流式细胞术分析了日本健康受试者（年龄范围：20-90岁；N = 356）的外周血单个核细胞。我们还评估了T细胞在抗cd3单克隆抗体刺激下的增殖活性和细胞因子产生能力。注意到T细胞、某些T细胞亚群（包括CD8+ T细胞、CD4+CDRA+ T细胞和CD8+CD28+ T细胞）和B细胞数量以及T细胞增殖能力的年龄相关性下降。除CD8+ T细胞数量外，这些免疫参数在男性中的下降速率大于女性（p < 0.05）。我们观察到CD4+ T细胞、CD4+CDRO+ T细胞和自然杀伤细胞（CD56+CD16+）的数量以及CD4+ T细胞/CD8+ T细胞比例的年龄相关增加或增加趋势。这些免疫指标的升高率女性高于男性（p < 0.05）。T细胞增殖指数（TCPI）由T细胞增殖活性和T细胞数量计算；结果显示，与年龄相关的衰退在男性中大于女性（p < 0.05）。使用5个T细胞参数计算的T细胞免疫评分也显示，男性的年龄相关衰退大于女性（p < 0.05）。此外，当淋巴细胞在抗cd3单克隆抗体刺激下培养时，观察到IFNγ、IL-2、IL-6和IL-10的产生有年龄相关的下降趋势。IL-6和IL-10分泌下降率男性高于女性（p < 0.05）。各种免疫参数的年龄相关变化在男性和女性之间是不同的。我们的研究结果表明，女性这些免疫参数的下降速度比男性慢，这与女性比男性长寿的事实是一致的。
Gender-related differences in humans are commonly observed in behaviour, physical activity, disease, and lifespan. However, the notion that age-related changes in the immune system differ between men and women remains controversial. To elucidate the relationship between immunological changes and lifespan, peripheral blood mononuclear cells from healthy Japanese subjects (age range: 20–90 years; N = 356) were analysed by using three-colour flow cytometry. The proliferative activities and cytokine-producing capacities of T cells in response to anti-CD3 monoclonal antibody stimulation were also assessed. An age-related decline in the number of T cells, certain subpopulations of T cells (including CD8+ T cells, CD4+CDRA+ T cells, and CD8+CD28+ T cells), and B cells, and in the proliferative capacity of T cells was noted. The rate of decline in these immunological parameters, except for the number of CD8+ T cells, was greater in men than in women (p < 0.05). We observed an age-related increase or increasing trend in the number of CD4+ T cells, CD4+CDRO+ T cells, and natural killer (CD56+CD16+) cells, as well as in the CD4+ T cell/CD8+ T cell ratio. The rate of increase of these immunological parameters was greater in women than in men (p < 0.05). T cell proliferation index (TCPI) was calculated from the T cell proliferative activity and the number of T cells; it showed an age-related decline that was greater in men than in women (p < 0.05). T cell immune score, which was calculated using 5 T cell parameters, also showed an age-related decline that was greater in men than in women (p < 0.05). Moreover, a trend of age-related decreases was observed in IFNγ, IL-2, IL-6, and IL-10 production, when lymphocytes were cultured with anti-CD3 monoclonal antibody stimulation. The rate of decline in IL-6 and IL-10 production was greater in men than in women (p < 0.05). Age-related changes in various immunological parameters differ between men and women. Our findings indicate that the slower rate of decline in these immunological parameters in women than that in men is consistent with the fact that women live longer than do men.
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影响因子：
3.9
作者：
Pietschmann, P;Gollob, E;Tragl, KH
通讯作者：
Tragl, KH
DOI：
10.1007/bf00694890
发表时间：
1984-01-01
期刊：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
影响因子：
--
作者：
SUZUKI, K;HIROKAWA, K;HATAKEYAMA, S
通讯作者：
HATAKEYAMA, S
影响因子：
1.9
作者：
Veneri, Dino;Franchini, Massimo;Ortolani, Riccardo
通讯作者：
Ortolani, Riccardo
影响因子：
5.3
作者：
UTSUYAMA, M;HIROKAWA, K;SATO, K
通讯作者：
SATO, K
影响因子：
5.3
作者：
Alberti, S.;Cevenini, E.;Monti, D.
通讯作者：
Monti, D.