Prevalence and predictors of phthalate exposure in pregnant women in Charleston, SC.
Prevalence and predictors of phthalate exposure in pregnant women in Charleston, SC.
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DOI：
10.1016/j.chemosphere.2017.11.019
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发表时间：
2018-03
期刊：
影响因子：
8.8
通讯作者：
Kucklick JR
中科院分区：
文献类型：
--
作者：
Wenzel AG;Brock JW;Cruze L;Newman RB;Unal ER;Wolf BJ;Somerville SE;Kucklick JR
邻苯二甲酸酯是一种增塑剂，由于广泛接触聚氯乙烯塑料、食品包装和个人护理产品，通常在人体尿液中检测到。几种邻苯二甲酸酯是已知的抗雄激素内分泌干扰物，这引起了人们对胎儿发育关键时期产前暴露的关注。虽然邻苯二甲酸盐接触是无处不在的，但某些人群受到更多或更少接触的影响。我们采集了居住在南卡罗来纳州查尔斯顿的378名怀孕中期妇女的尿样，并检测了8种邻苯二甲酸酯代谢产物作为邻苯二甲酸酯暴露的生物标志物：邻苯二甲酸单丁酯(MBP)、邻苯二甲酸单丁酯(MBZP)、邻苯二甲酸单(2-乙基己基)酯(MEHP)、邻苯二甲酸单乙酯(MEOHP)、邻苯二甲酸单(2-乙基-5-羟基己基)邻苯二甲酸单酯(MEHHP)、邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单异丁酯(MiBP)和邻苯二甲酸单甲酯(MMP)。人口统计数据是从样本收集时发放的问卷中收集的。在93%以上的尿样中检测到所有邻苯二甲酸盐代谢物。平均而言，MEP的浓度最高(中位数为47.0 ng/m L)，而基质金属蛋白酶的浓度最低(中位数为1.92 ng/m L)。与邻苯二甲酸酯浓度升高相关的社会人口学特征包括未婚、受教育程度低、低收入、高体重指数(BMI)和/或非裔美国人。经过种族分层后，在非裔美国女性中，年龄、体重指数、教育程度和收入与邻苯二甲酸盐浓度显著相关。在高加索女性中，婚姻状况只与邻苯二甲酸盐浓度有关，而在未婚女性中，MBP、MEHHP、MBP和基质金属蛋白酶的浓度高于已婚女性。这项横断面研究的结果为邻苯二甲酸盐暴露的显著种族和人口统计学差异提供了证据。
Phthalates are plasticizers commonly detected in human urine due to widespread exposure from PVC plastics, food packaging, and personal care products. Several phthalates are known antiandrogenic endocrine disruptors, which raises concern for prenatal exposure during critical windows of fetal development. While phthalate exposure is ubiquitous, certain demographics are subject to greater or lesser exposure. We sampled urine from 378 pregnant women during the second trimester of gestation living in Charleston, SC, and measured eight urinary phthalate metabolites as biomarkers of phthalate exposure: monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), monoethyl phthalate (MEP), monoisobutyl phthalate (MiBP), and monomethyl phthalate (MMP). Demographic data was collected from questionnaires administered at the time of specimen collection. All phthalate metabolites were detected in over 93% of urine samples. On average, concentrations were highest for MEP (median = 47.0 ng/mL) and lowest for MMP (median = 1.92 ng/mL). Sociodemographic characteristics associated with elevated phthalate concentrations included being unmarried, less educated, having a low income, high body mass index (BMI), and/or being African American. After racial stratification, age, BMI, education, and income were significantly associated with phthalate concentrations in African American women. Marital status was associated with phthalate concentrations in Caucasian women only, with greater concentrations of MBP, MEHHP, MiBP, and MMP in unmarried versus married women. Results of this cross-sectional study provide evidence for significant racial and demographic variations in phthalate exposure.
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影响因子：
11.4
作者：
Guo, Ying;Kannan, Kurunthachalam
通讯作者：
Kannan, Kurunthachalam
影响因子：
10.4
作者：
Colacino JA;Harris TR;Schecter A
通讯作者：
Schecter A
DOI：
10.1186/s12940-015-0043-6
发表时间：
2015-07-15
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Branch F;Woodruff TJ;Mitro SD;Zota AR
通讯作者：
Zota AR
影响因子：
7.9
作者：
Calafat, Antonia M;Valentin-Blasini, Liza;Ye, Xiaoyun
通讯作者：
Ye, Xiaoyun
影响因子：
4.9
作者：
Casals-Casas, C.;Feige, J. N.;Desvergne, B.
通讯作者：
Desvergne, B.