Segregation and linkage analyses of bipolar and major depressive illnesses in multigenerational pedigrees.
Segregation and linkage analyses of bipolar and major depressive illnesses in multigenerational pedigrees.
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多代谱系中双相情感障碍和重度抑郁症的分离和连锁分析。
DOI：
10.1016/0022-3956(89)90002-2
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发表时间：
1989
影响因子：
4.8
通讯作者：
Keats,B
中科院分区：
文献类型：
--
作者：
Cox,N;Reich,T;Rice,J;Elston,R;Schober,J;Keats,B
收集了六个大型多代家系的数据，其中四个是通过一个患有重度抑郁症的先证者确定的，两个是通过一个患有双相情感障碍的先证者确定的。使用SADS-L结构化访谈和研究诊断标准（RDC）进行诊断。使用允许主要基因座和多基因遗传的模型对双相抑郁症和重性抑郁症谱系集进行了复杂的分离分析;在这些分析中，检查了有关终生人群患病率的各种诊断方案和假设。使用分离分析得出的疾病易感性传递参数对标准标记进行连锁分析。分离分析的结果是相当敏感的诊断和患病率的假设。在通过双极型疾病先证者确定的家系中，我们无法区分主基因和多基因遗传。当双相情感性躁狂和双相情感性躁狂被认为是受影响的，终生人群患病率在0.04和0.06之间时，这些数据与疾病易感性的孟德尔主基因传递是相容的。在这一狭窄的患病率范围之外，或者当其他诊断，如重度抑郁症或轻躁狂症，被纳入作为疾病易感性的表达时，疾病易感性的主要基因传播可以被拒绝。同样，在通过重度抑郁症先证者确定的家系中，通常不可能区分疾病易感性的主基因和多基因传递。对于仅将重度抑郁症作为疾病易感性表现的诊断方案，终生人群患病率值的范围很窄（女性患病率范围为0.20至0.25，男性患病率设定为女性患病率的1/2），这产生了与主要基因传播相容的结果。所有标记的连锁分析均产生阴性或不确定的结果。在一个双极家系中，发现1号染色体上有一个标记，LOD值为1.65，建议对该染色体进行进一步研究。
Data were collected on six large multigenerational pedigrees, four ascertained through a proband with major depression and two ascertained through a proband with a bipolar form of illness. Diagnoses were made using the SADS-L structured interview and Research Diagnostic Criteria (RDC). Complex segregation analyses were conducted on the bipolar and the major depression pedigree sets using a model allowing for both major locus and polygenic inheritance; in these analyses a variety of diagnostic schemes and assumptions concerning the lifetime population prevalence were examined. Linkage analyses on standard markers were conducted using parameters for transmission of susceptibility to illness derived from the segregation analyses. Results of the segregation analyses were quite sensitive to the diagnostic and prevalence assumptions. In the pedigrees ascertained through probands with a bipolar form of illness, we were unable to discriminate between major gene and polygenic inheritance. The data were compatible with Mendelian major gene transmission of susceptibility to illness when bipolar and schizoaffective manic diagnoses were considered as affected and the lifetime population prevalence was between 0.04 and 0.06. Outside this narrow prevalence range, or when additional diagnoses, such as major depression or hypomania, were included as expressions of liability to disease, major gene transmission of susceptibility to disease could be rejected. Similarly, in the pedigrees ascertained through probands with major depression, it was not generally possible to discriminate between major gene and polygenic transmission of susceptibility to illness. For a diagnostic scheme including only major depression as a manifestation of susceptibility to illness, there was a narrow range of lifetime population prevalence values (female prevalence ranging from 0.20 to 0.25, male prevalence set to 1/2 female prevalence) which yielded results compatible with major gene transmission. Linkage analyses for all markers yielded negative or inconclusive results. In one bipolar pedigree a lod score of 1.65 was found with a marker in chromosome 1 recommending further studies of this chromosome.
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色盲与双相情感障碍没有密切关系。
影响因子：
--
作者：
Elliot S. Gershon;Targum Sd;Steven Matthysse;William E. Bunney
通讯作者：
William E. Bunney
与 HLA 无关的情感障碍。
影响因子：
2.1
作者：
Price,RA
通讯作者：
Price,RA
影响因子：
64.8
作者：
HODGKINSON, S;SHERRINGTON, R;BRYNJOLFSSON, J
通讯作者：
BRYNJOLFSSON, J
躁狂抑郁症：与 Xg 血型的联系。
DOI：
10.1176/ajp.130.12.1355
发表时间：
1973
期刊：
The American journal of psychiatry
影响因子：
--
作者：
R. Fieve;J. Mendlewicz;J. Fleiss
通讯作者：
J. Fleiss
影响因子：
3.2
作者：
R. Crowe;K. Namboodiri;H. Ashby;R. Elston
通讯作者：
R. Elston