Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase.
Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase.
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DOI：
10.3164/jcbn.10-116
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发表时间：
2011-07
影响因子：
2.4
通讯作者：
Wongsasiripat N
中科院分区：
文献类型：
--
作者：
Adisakwattana S;Yibchok-Anun S;Charoenlertkul P;Wongsasiripat N
测定了氰基-3-芦丁糖苷在体内外对肠道α-葡萄糖苷酶的抑制作用。氰基-3-芦丁糖苷对肠麦芽糖酶和蔗糖酶的IC_(50)分别为2323±14.8和250.2±8.1µM。动力学分析表明，氰基-3-芦丁糖苷对肠道蔗糖酶具有混合型抑制作用。氰基-3-芦丁糖苷与阿卡波糖合用对肠道麦芽糖酶和蔗糖酶也有协同抑制作用。正常大鼠灌胃给予花青素-3-芦丁糖苷(100和300 mg/kg)加麦芽糖或蔗糖后，餐后30~90分钟血糖明显降低。此外，正常大鼠经阿卡波糖和氰基-3-芦丁糖苷(30 mg/kg)治疗后，餐后血糖的下降幅度大于阿卡波糖单独治疗组。这些结果表明，花青素-3-芦丁糖苷通过抑制α-葡萄糖苷酶来抑制碳水化合物的吸收，这可能是一种潜在的糖尿病预防和治疗的抑制剂。
The inhibitory activity on intestinal α-glucosidase by cyanidin-3-rutinoside was examined in vitro and in vivo. The IC50 values of cyanidin-3-rutinoside against intestinal maltase, and sucrase were 2,323 ± 14.8 and 250.2 ± 8.1 µM, respectively. The kinetic analysis revealed that intestinal sucrase was inhibited by cyanidin-3-rutinoside in a mixed-type manner. The synergistic inhibition also found in combination of cyanidin-3-rutinoside with acarbose against intestinal maltase and sucrase. The oral administration of cyanidin-3-rutinoside (100 and 300 mg/kg) plus maltose or sucrose to normal rats, postprandial plasma glucose was markedly suppressed at 30–90 min after loading. Furthermore, the normal rats treated with acarbose and cyanidin-3-rutinoside (30 mg/kg) showed greater reduction of postprandial plasma glucose than the group treated with acarbose alone. These results suggest that cyanidin-3-rutinoside retards absorption of carbohydrates by inhibition of α-glucosidase which may be useful as a potential inhibitor for prevention and treatment of diabetes mellitus.
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影响因子：
5.6
作者：
Akkarachiyasit S;Charoenlertkul P;Yibchok-Anun S;Adisakwattana S
通讯作者：
Adisakwattana S
影响因子：
9.7
作者：
Chen, Pei-Ni;Chu, Shu-Chen;Hsieh, Yih-Shou
通讯作者：
Hsieh, Yih-Shou
影响因子：
1.3
作者：
Qin, Chuanguang;Li, Yang;Shang, Xiaoya
通讯作者：
Shang, Xiaoya
影响因子：
4.5
作者：
Hassimotto, Neuza Mariko Ayrnoto;Genovese, Maria Ines;Lajolo, Franco Maria
通讯作者：
Lajolo, Franco Maria
影响因子：
1.8
作者：
ELHABIRI, M;FIGUEIREDO, P;BROUILLARD, R
通讯作者：
BROUILLARD, R