The Evolution of STING Signaling and Its Involvement in Cancer.
The Evolution of STING Signaling and Its Involvement in Cancer.
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STING信号传导的演变及其在癌症中的参与
DOI：
10.1016/j.tibs.2020.12.010
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发表时间：
2021-06
影响因子：
13.8
通讯作者：
Bakhoum SF
中科院分区：
文献类型：
--
作者：
Vashi N;Bakhoum SF
cGAS-STING途径已被主要表征为高等真核生物中响应于胞质双链DNA的存在的炎症反应机制。自其最初发现以来，已经发现了描绘其不同组分和下游信号传导的动态亚细胞定位的详细机制，从而尝试利用其促炎特性来治疗癌症。然而，新出现的证据表明，STING的一个关键的原始功能是促进自噬，并且下游干扰素信号传导最近在其进化史中发生。此外，研究表明，该途径是细胞代谢的关键调节剂，可能将炎症与营养物质的可用性相结合。在这篇综述中，我们专注于STING的进化保守功能，并讨论如何更广泛地了解这一途径可以帮助我们更好地了解其在癌症中的潜在作用，并利用它的治疗效益。
The cGAS-STING pathway has been primarily characterized as an inflammatory response mechanism in higher eukaryotes in response to the presence of cytosolic double-stranded DNA. Since its initial discovery, detailed mechanisms delineating the dynamic subcellular localization of its different components and downstream signaling have been uncovered, leading to attempts that harness its pro-inflammatory properties for therapeutic benefits in cancer. Emerging evidence, however, indicates that a critical primordial function of STING is to promote autophagy and that downstream interferon signaling has occurred recently in its evolutionary history. Furthermore, studies suggest that this pathway is a critical regulator of cellular metabolism potentially coupling inflammation to nutrient availability. In this review, we focus on the evolutionarily conserved functions of STING and discuss how a broader understanding of this pathway can help us better appreciate its potential role in cancer and harness it for a therapeutic benefit.
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影响因子：
64.8
作者：
通讯作者：
--
染色体不稳定性通过胞质DNA反应驱动转移。
影响因子：
64.8
作者：
Bakhoum SF;Ngo B;Laughney AM;Cavallo JA;Murphy CJ;Ly P;Shah P;Sriram RK;Watkins TBK;Taunk NK;Duran M;Pauli C;Shaw C;Chadalavada K;Rajasekhar VK;Genovese G;Venkatesan S;Birkbak NJ;McGranahan N;Lundquist M;LaPlant Q;Healey JH;Elemento O;Chung CH;Lee NY;Imielenski M;Nanjangud G;Pe'er D;Cleveland DW;Powell SN;Lammerding J;Swanton C;Cantley LC
通讯作者：
Cantley LC
ATM 和 IFI16 对 DNA 传感适配器 STING 的非规范激活可在核 DNA 损伤后介导 NF-κB 信号转导。
影响因子：
16
作者：
Dunphy G;Flannery SM;Almine JF;Connolly DJ;Paulus C;Jønsson KL;Jakobsen MR;Nevels MM;Bowie AG;Unterholzner L
通讯作者：
Unterholzner L
DOI：
10.1196/annals.1299.139
发表时间：
2003-01-01
期刊：
APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
影响因子：
--
作者：
Driessens, G;Harsan, L;Bruyns, C
通讯作者：
Bruyns, C
影响因子：
4
作者：
Dillekas, Hanna;Rogers, Michael S.;Straume, Oddhjorn
通讯作者：
Straume, Oddhjorn