Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus.
Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus.
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DOI：
10.1155/2012/895185
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发表时间：
2012
影响因子：
--
通讯作者：
McTernan PG
中科院分区：
文献类型：
--
作者：
Harte AL;da Silva NF;Miller MA;Cappuccio FP;Kelly A;O'Hare JP;Barnett AH;Al-Daghri NM;Al-Attas O;Alokail M;Sabico S;Tripathi G;Bellary S;Kumar S;McTernan PG
对于给定的BMI，南亚人患2型糖尿病(T2 DM)和心血管疾病(CVD)的风险比白人高。通过端粒长度(TL)的减少来评估过早的生物衰老，可能是由与肥胖相关的代谢谱改变引起的因素所介导的。我们假设种族和新陈代谢状态是导致生物过早老化的有害因素。因此，我们评估了两个南亚人、年龄和BMI匹配的队列中的TL[T2 DM(n=142)与非T2 DM(n=76)]，以确定BMI、性别、血脂和心血管疾病特征对生物衰老的影响。从UKADS队列中获取基因组DNA；收集生化和人体测量数据，并用实时定量聚合酶链式反应测定TL。我们的研究结果表明，与非T2 DM男性相比，T2 DM男性的TL降低(P=0.006)。此外，在T2 DM男性中，TL与甘油三酯和总胆固醇呈负相关(r=−0.419，P<0.01；r=−0.443，P<0.01)。总而言之，南亚T2 DM男性的TL降低，并与甘油三酯和总胆固醇相关。这项研究强调了南亚2型糖尿病男性的生物衰老加剧，这似乎是由血脂和BMI的变化跟踪的，这表明血脂升高和BMI可能直接导致过早衰老。
South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = −0.419, P < 0.01; r = −0.443, P < 0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.
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影响因子：
4.5
作者：
Nordfjall, Katarina;Svenson, Ulrika;Norrback, Karl-Fredrik;Adolfsson, Rolf;Lenner, Per;Roos, Goran
通讯作者：
Roos, Goran
影响因子：
2.9
作者：
Lin, Jue;Kroenke, Candyce H.;Rasgon, Natalie L.
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加强对南亚裔患者的糖尿病护理（英国亚裔糖尿病研究）：分组随机对照试验
影响因子：
168.9
作者：
Bellary, S.;O'Hare, J. P.;Barnett, A. H.
通讯作者：
Barnett, A. H.
影响因子：
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作者：
Cohen, Hagit;Yehuda, Rachel
通讯作者：
Yehuda, Rachel
影响因子：
8.3
作者：
Benetos, A;Okuda, K;Aviv, A
通讯作者：
Aviv, A