Antitumor activity of FCE 26644 a new growth-factor complexing molecule
Antitumor activity of FCE 26644 a new growth-factor complexing molecule
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新型生长因子复合分子 FCE 26644 的抗肿瘤活性
DOI：
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发表时间：
2004
影响因子：
3
通讯作者：
M. Grandi
中科院分区：
文献类型：
--
作者：
F. Sola;M. Farao;E. Pesenti;A. Marsiglio;N. Mongelli;M. Grandi
FCE 26644, or 7,7′-(carbonyl-bis[imino-N-methyl-4, 2 pyrrole carbonyl-imino{N-methyl-4, 2-pyrrole}carbonylimino])-bis-(1, 3-naphthalene)disulfonic acid, belongs to the newly synthesized class of sulfonated derivatives of distamycin A. FCE 26644 is a noncytotoxic molecule capable of inhibiting the binding of basic fibreblast growth factor (bFGF), platelet-derived growth factor (PDGFβ) and interleukin 1 (IL-7) to their receptors and to block bFGF-induced vascularization in vivo as well as neovascularization in the chorioallantoic membrane. FCE 26644 and suramin, a compound possessing the same terminal half-life (t1/2) in mice and, presumably, the same mode of action, inhibit the growth of solid murine tumors, M5076 reticulosarcoma, and MXT and S180 fibrosarcoma and are inactive against B16F10 melanoma. The activity of FCE 26644 was constantly observed at nontoxic doses, at variance with suramin. FCE 26644 was also found to maintain activity against M5076 resistant to cyclophosphamide and to be equally active against UV 2237 and UV 2237/ADR fibrosarcoma.
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影响因子：
56.9
作者：
Jan Thompson;Anderson Kd;JM DiPietro;J. Zwiebel;M. Zametta;W. Anderson;T. Maciag
通讯作者：
Jan Thompson;Anderson Kd;JM DiPietro;J. Zwiebel;M. Zametta;W. Anderson;T. Maciag
影响因子：
158.5
作者：
WEIDNER, N;SEMPLE, JP;FOLKMAN, J
通讯作者：
FOLKMAN, J
DOI：
10.1073/pnas.90.5.1937
发表时间：
1993-03-01
影响因子：
11.1
作者：
GRANT, DS;KLEINMAN, HK;ROSEN, EM
通讯作者：
ROSEN, EM
肿瘤生长依赖于多硫酸戊聚糖抑制的卡波西肉瘤来源的成纤维细胞生长因子。
DOI：
10.1093/jnci/83.10.716
发表时间：
1991
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Wellstein,A;Zugmaier,G;Califano3rd,JA;Kern,F;Paik,S;Lippman,ME
通讯作者：
Lippman,ME
影响因子：
56.9
作者：
AARONSON, SA
通讯作者：
AARONSON, SA