Design and application of nanoparticles as vaccine adjuvants against human corona virus infection.

Design and application of nanoparticles as vaccine adjuvants against human corona virus infection.
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纳米粒子作为抗人冠状病毒感染疫苗佐剂的设计与应用

DOI:
10.1016/j.jinorgbio.2021.111454
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发表时间:
2021-06
影响因子:
3.9
通讯作者:
Chen C
Chen C
中科院分区:
生物学2区
文献类型:
--
作者:
Mao L;Chen Z;Wang Y;Chen C

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近年来,一些病毒给全球公共卫生造成了严重危机,尤其是人类冠状病毒。因此,迫切需要一种真正有效的疫苗。疫苗一般应具有两个特点:传递抗原和调节免疫。佐剂在对抗病毒的战斗中有着不可动摇的地位。除了铝佐剂的长期使用外,纳米颗粒由于其独特的性能已成为发展中的佐剂候选物。本文介绍几种典型的纳米颗粒及其在抗病毒疫苗佐剂中的应用。最后,针对抗击冠状病毒,我们提出了几个设计要点,希望为个性化疫苗和佐剂的开发提供思路,加快佐剂的临床应用。几种典型的纳米颗粒是疫苗佐剂的潜在候选者,可以保护人类免受冠状病毒感染。
In recent years, some viruses have caused a grave crisis to global public health, especially the human coronavirus. A truly effective vaccine is therefore urgently needed. Vaccines should generally have two features: delivering antigens and modulating immunity. Adjuvants have an unshakable position in the battle against the virus. In addition to the perennial use of aluminium adjuvant, nanoparticles have become the developing adjuvant candidates due to their unique properties. Here we introduce several typical nanoparticles and their antivirus vaccine adjuvant applications. Finally, for the combating of the coronavirus, we propose several design points, hoping to provide ideas for the development of personalized vaccines and adjuvants and accelerate the clinical application of adjuvants. Several typical nanoparticles are potential candidates for vaccine adjuvants, protecting human beings from coronavirus infections.
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