The effect of ambient air pollution on exhaled nitric oxide in the Children's Health Study.
The effect of ambient air pollution on exhaled nitric oxide in the Children's Health Study.
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DOI：
10.1183/09031936.00081410
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Gilliland FD
中科院分区：
文献类型：
--
作者：
Berhane K;Zhang Y;Linn WS;Rappaport EB;Bastain TM;Salam MT;Islam T;Lurmann F;Gilliland FD
我们评估了环境空气污染物的每日变化对呼出的一氧化氮（FeNO）的影响，使用的数据来自一个队列的学龄儿童的空气污染物暴露的儿童健康研究有很大的差异。基于一个队列的2240名学童从13个南加州社区，累积滞后平均回归模型进行拟合，以确定FeNO和环境空气污染水平之间的关联，从中央站点监测器与滞后长达30天之前，FeNO测试。PM2.5日24小时累积滞后平均值（1-8天）和PM10（超过1-7天），以及上午10点至下午6点的O3累积滞后平均值（1-23天）显著相关17.42%四分位数范围分别为7.5 μg/m3、12.97 μg/m3和15.42 ppb时，FeNO水平分别升高9.25%（P<0.05）和14.25%（P<0.01）。暖季PM2.5、PM10和O3的影响较大。PM的影响是强大的O3和温度的影响调整，并没有改变哮喘或过敏状态。总之，PM2.5、PM10和O3的短期增加与气道炎症相关，与哮喘和过敏状态无关，PM10的影响在温暖的季节显著更高。
We assessed the effect of daily variations in ambient air pollutants on exhaled nitric oxide (FeNO) using data from a cohort of schoolchildren with large differences in air pollutant exposures from the Children’s Health Study. Based on a cohort of 2240 schoolchildren from 13 Southern California communities, cumulative lagged average regression models were fitted to determine the association between FeNO and ambient air pollution levels from central site monitors with lags of up to 30 days prior to FeNO testing. Daily 24-hr cumulative lagged averages of PM2.5 (over 1–8 days) and PM10 (over 1–7 days), as well as 10AM–6PM cumulative lagged average of O3 (over 1–23 days) were significantly associated with 17.42% (p<0.01), 9.25% (P<0.05) and 14.25% (p<0.01) higher FeNO levels over the inter-quartile range of 7.5 μg/m3, 12.97 μg/m3, and 15.42 ppb, respectively. The effects of PM2.5, PM10 and O3 were higher in the warm season. The PM effects were robust to adjustments for effects of O3 and temperature and did not vary by asthma or allergy status. In Summary, short-term increases in PM2.5, PM10, and O3 were associated with airway inflammation independent of asthma and allergy status, with PM10 effects significantly higher in the warm season.
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影响因子：
10.4
作者：
通讯作者：
--
DOI：
10.1007/s00420-002-0320-x
发表时间：
2002-06-01
影响因子：
3
作者：
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通讯作者：
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10.4
作者：
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通讯作者：
Peters, JM
DOI：
10.1164/ajrccm.159.3.9804144
发表时间：
1999-03-01
影响因子：
24.7
作者：
Peters, JM;Avol, E;Thomas, DC
通讯作者：
Thomas, DC
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society