Origins of correlated activity in an olfactory circuit.
Origins of correlated activity in an olfactory circuit.
复制标题
嗅觉电路中相关活性的起源。
DOI:
10.1038/nn.2376
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发表时间:
2009-09
影响因子:
25
通讯作者:
Wilson RI
中科院分区:
文献类型:
--
作者:
Kazama H;Wilson RI
Multineuronal recordings often reveal synchronized spikes in different neurons. How correlated spike timing affects neural codes depends on the statistics of correlations, which in turn reflects the connectivity that gives rise to correlations. However, determining the connectivity of neurons recorded in vivo can be difficult. Here, we investigate the origins of correlated activity in genetically-labeled neurons of the Drosophila antennal lobe. Dual recordings show synchronized spontaneous spikes in projection neurons (PNs) postsynaptic to the same type of olfactory receptor neuron (ORN). Odors increase these correlations. The primary origin of correlations lies in the divergence of each ORN onto every PN in its glomerulus. Reciprocal PN-PN connections make a smaller contribution to correlations, and PN spike trains in different glomeruli are only weakly correlated. PN axons from the same glomerulus reconverge in the lateral horn, where pooling redundant signals may allow lateral horn neurons to average out noise that arises independently in these PNs.
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影响因子:
16.2
作者:
Christie, JM;Bark, C;Westbrook, GL
通讯作者:
Westbrook, GL
影响因子:
16.2
作者:
Olsen, Shawn R.;Bhandawat, Vikas;Wilson, Rachel I.
通讯作者:
Wilson, Rachel I.
影响因子:
56.9
作者:
MEISTER, M;LAGNADO, L;BAYLOR, DA
通讯作者:
BAYLOR, DA
影响因子:
56.9
作者:
Perez-Orive, J;Mazor, O;Laurent, G
通讯作者:
Laurent, G
DOI:
10.1007/bf00271538
发表时间:
1991-01-01
期刊:
HISTOCHEMISTRY
影响因子:
--
作者:
MALUN, D
通讯作者:
MALUN, D