Origins of correlated activity in an olfactory circuit.

Origins of correlated activity in an olfactory circuit.
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嗅觉电路中相关活性的起源。

DOI:
10.1038/nn.2376
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发表时间:
2009-09
影响因子:
25
通讯作者:
Wilson RI
Wilson RI
中科院分区:
医学1区
文献类型:
--
作者:
Kazama H;Wilson RI

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多神经元记录经常显示不同神经元中的同步棘波。相关的尖峰时间对神经编码的影响取决于相关性的统计数据,而相关性的统计又反映了产生相关性的连接性。然而,确定活体记录的神经元的连接性可能是困难的。在这里,我们调查了果蝇触角叶基因标记神经元相关活动的来源。双重记录显示投射神经元(PNS)与同类型嗅觉感受器神经元(ORN)突触后的自发放电同步。气味增加了这些相关性。相关性的主要来源在于每个ORN在其肾小球中的每个PN上的分歧。相互的PN-PN连接对相关性的贡献较小,不同肾小球的PN峰序列仅有微弱的相关性。来自同一肾小球的PN轴突重新汇聚在侧角,在那里汇集冗余信号可能允许侧角神经元平均这些PNS中独立产生的噪声。
Multineuronal recordings often reveal synchronized spikes in different neurons. How correlated spike timing affects neural codes depends on the statistics of correlations, which in turn reflects the connectivity that gives rise to correlations. However, determining the connectivity of neurons recorded in vivo can be difficult. Here, we investigate the origins of correlated activity in genetically-labeled neurons of the Drosophila antennal lobe. Dual recordings show synchronized spontaneous spikes in projection neurons (PNs) postsynaptic to the same type of olfactory receptor neuron (ORN). Odors increase these correlations. The primary origin of correlations lies in the divergence of each ORN onto every PN in its glomerulus. Reciprocal PN-PN connections make a smaller contribution to correlations, and PN spike trains in different glomeruli are only weakly correlated. PN axons from the same glomerulus reconverge in the lateral horn, where pooling redundant signals may allow lateral horn neurons to average out noise that arises independently in these PNs.
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