Maternal diet quality moderates associations between parabens and birth outcomes.
Maternal diet quality moderates associations between parabens and birth outcomes.
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DOI：
10.1016/j.envres.2022.114078
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发表时间：
2022-11
影响因子：
8.3
通讯作者：
Strakovsky, Rita S.
中科院分区：
文献类型：
--
作者：
Pacyga, Diana C.;Talge, Nicole M.;Gardiner, Joseph C.;Calafat, Antonia M.;Schantz, Susan L.;Strakovsky, Rita S.
母亲接触对羟基苯甲酸酯和饮食质量都与出生结果独立相关，但这些因素是否相互作用尚不清楚。我们通过母亲的饮食质量评估了特定性别的对羟基苯甲酸酯与分娩结局和差异的关系。伊利诺伊州孕妇(n=458)提供了怀孕8-40周时收集的5个清晨尿液，我们将这些尿液汇集在一起，用于量化对羟基苯甲酸乙酯、对羟基苯甲酸甲酯和对羟基苯甲酸丙酯的浓度。我们收集/测量了分娩时的胎龄、出生体重、身长和出生后24小时内的头围，并计算了性别特定的出生体重与胎龄的z分数和体重/身长比。女性在怀孕早期和中晚期完成了为期三个月的食物频率调查问卷，我们用这些问卷计算了2010年替代健康饮食指数(AHEI)。线性回归模型评估了特定性别的对羟基苯甲酸酯与出生结局的关联，以及按平均妊娠情况的关联差异。在这个以非西班牙裔白人为主、受过大学教育的样本中，母亲尿中的Paraben浓度与头围和妊娠长度呈适度的负相关。然而，在女性中，对羟基苯甲酸甲酯和对羟基苯甲酸丙酯与出生体重、出生体重z分数、体长和体重/长度比呈负相关，但与男性新生儿无关。例如，在女性中，甲基对羟基苯甲酸酯浓度每增加2倍，就会导致−46.5g(95%CI：−74.6，−18.3)出生体重降低，−0.10(95%CI：−0.16，−0.03)出生体重z分数降低，−0.20 cm(95%CI：−0.33，−0.07)体长缩短，−0.6g/cm(95%CI：−1.1，−0.2)体重/长度比降低。这些反向关联在饮食较差的母亲中更为显著(AHEI-2010年中位数)，但在饮食较健康的母亲中减弱(AHEI-2010≥中值)。在母亲饮食更健康的新生儿男性中，对羟基苯甲酸丙酯与孕长和头围呈中度负相关。母亲的饮食可能会以特定性别的方式缓和对羟基苯甲酸酯与出生大小的关联。其他研究可能会考虑在其他人群中证实这些发现。
Maternal paraben exposure and diet quality are both independently associated with birth outcomes, but whether these interact is unknown. We assessed sex-specific associations of parabens with birth outcomes and differences by maternal diet quality. Illinois pregnant women (n=458) provided five first-morning urines collected at 8–40 weeks gestation, which we pooled for quantification of ethylparaben, methylparaben, and propylparaben concentrations. We collected/measured gestational age at delivery, birth weight, body length, and head circumference within 24 hours of birth, and calculated sex-specific birth weight-for-gestational-age z-scores and weight/length ratio. Women completed three-month food frequency questionnaires in early and mid-to-late pregnancy, which we used to calculate the Alternative Healthy Eating Index (AHEI)-2010. Linear regression models evaluated sex-specific associations of parabens with birth outcomes, and differences in associations by average pregnancy AHEI-2010. In this predominately non-Hispanic white, college-educated sample, maternal urinary paraben concentrations were modestly inversely associated with head circumference and gestational length. However, methylparaben and propylparaben were inversely associated with birth weight, birth weight z-scores, body length, and weight/length ratio in female, but not male newborns. For example, each 2-fold increase in methylparaben concentrations was associated with −46.5 g (95% CI: −74.6, −18.3) lower birth weight, −0.10 (95% CI: −0.16, −0.03) lower birth weight z-scores, −0.20 cm (95% CI: −0.33, −0.07) shorter body length, and −0.6 g/cm (95% CI: −1.1, −0.2) smaller weight/length ratio in females. These inverse associations were more prominent in females of mothers with poorer diets (AHEI-2010 < median), but attenuated in those with healthier diets (AHEI-2010 ≥ median). In newborn males of mothers with healthier diets, moderate inverse associations emerged for propylparaben with gestational length and head circumference. Maternal diet may moderate associations of parabens with birth size in a sex-specific manner. Additional studies may consider corroborating these findings in other populations.
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影响因子：
11.8
作者：
Bräuner EV;Uldbjerg CS;Lim YH;Gregersen LS;Krause M;Frederiksen H;Andersson AM
通讯作者：
Andersson AM
影响因子：
8.3
作者：
Aker, Amira M.;Watkins, Deborah J.;Johns, Lauren E.;Ferguson, Kelly K.;Soldin, Offie P.;Del Toro, Liza V. Anzalota;Alshawabkeh, Akram N.;Cordero, Jose F.;Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
2.5
作者：
Ahn, Hyo-Jin;An, Beum-Soo;Jeung, Eui-Bae
通讯作者：
Jeung, Eui-Bae
影响因子：
7.9
作者：
Cowell WJ;Wright RJ
通讯作者：
Wright RJ
影响因子：
8.3
作者：
Bellavia A;Chiu YH;Brown FM;Mínguez-Alarcón L;Ford JB;Keller M;Petrozza J;Williams PL;Ye X;Calafat AM;Hauser R;James-Todd T;EARTH Study Team
通讯作者：
EARTH Study Team