Regulatory landscape in brain development and disease.
Regulatory landscape in brain development and disease.
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大脑发育和疾病中的调节景观。
DOI：
10.1016/j.gde.2020.05.007
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发表时间：
2020-12
影响因子：
4
通讯作者：
Won H
中科院分区：
文献类型：
--
作者：
Spiess K;Won H
尽管非编码基因组中的许多调控元件与大脑发育和疾病有关，但由于缺乏基因组工具箱，破译它们的功能一直是一个挑战。然而，高通量测序技术的最新进展使我们能够开始解码其功能，增强了我们对支撑人类特征和大脑疾病的调控格局的理解。在这里，我们回顾了人类大脑的调节格局如何经历神经发育、不同细胞类型和人类进化的动态变化。然后，我们讨论监管环境如何阐明神经精神障碍的分子基础，并指导特定靶向分子疗法的发展。最后，我们提供了一些关于这些发现可能如何影响未来研究方向的思考。
Although many regulatory elements in the non-coding genome are linked to brain development and disease, deciphering their function has been challenging due to the lack of a genomic toolbox. However, recent advances in high throughput sequencing techniques have allowed us to begin decoding its function, enhancing our understanding of the regulatory landscape that underpins human traits and brain disorders. Here, we review how the regulatory landscape of the human brain undergoes dynamic changes across neurodevelopment, different cell types, and human evolution. We then discuss how regulatory landscapes shed light onto the molecular basis of neuropsychiatric disorders and guide the development of specifically targeted molecular therapies. Finally, we offer some thoughts on how these discoveries might impact the direction of future studies.
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影响因子：
64.5
作者：
de la Torre-Ubieta L;Stein JL;Won H;Opland CK;Liang D;Lu D;Geschwind DH
通讯作者：
Geschwind DH
影响因子：
64.5
作者：
Dekker J;Mirny L
通讯作者：
Mirny L
影响因子：
25
作者：
Gouwens NW;Sorensen SA;Berg J;Lee C;Jarsky T;Ting J;Sunkin SM;Feng D;Anastassiou CA;Barkan E;Bickley K;Blesie N;Braun T;Brouner K;Budzillo A;Caldejon S;Casper T;Castelli D;Chong P;Crichton K;Cuhaciyan C;Daigle TL;Dalley R;Dee N;Desta T;Ding SL;Dingman S;Doperalski A;Dotson N;Egdorf T;Fisher M;de Frates RA;Garren E;Garwood M;Gary A;Gaudreault N;Godfrey K;Gorham M;Gu H;Habel C;Hadley K;Harrington J;Harris JA;Henry A;Hill D;Josephsen S;Kebede S;Kim L;Kroll M;Lee B;Lemon T;Link KE;Liu X;Long B;Mann R;McGraw M;Mihalas S;Mukora A;Murphy GJ;Ng L;Ngo K;Nguyen TN;Nicovich PR;Oldre A;Park D;Parry S;Perkins J;Potekhina L;Reid D;Robertson M;Sandman D;Schroedter M;Slaughterbeck C;Soler-Llavina G;Sulc J;Szafer A;Tasic B;Taskin N;Teeter C;Thatra N;Tung H;Wakeman W;Williams G;Young R;Zhou Z;Farrell C;Peng H;Hawrylycz MJ;Lein E;Ng L;Arkhipov A;Bernard A;Phillips JW;Zeng H;Koch C
通讯作者：
Koch C
影响因子：
30.8
作者：
Finucane HK;Reshef YA;Anttila V;Slowikowski K;Gusev A;Byrnes A;Gazal S;Loh PR;Lareau C;Shoresh N;Genovese G;Saunders A;Macosko E;Pollack S;Brainstorm Consortium;Perry JRB;Buenrostro JD;Bernstein BE;Raychaudhuri S;McCarroll S;Neale BM;Price AL
通讯作者：
Price AL
影响因子：
25
作者：
Girdhar K;Hoffman GE;Jiang Y;Brown L;Kundakovic M;Hauberg ME;Francoeur NJ;Wang YC;Shah H;Kavanagh DH;Zharovsky E;Jacobov R;Wiseman JR;Park R;Johnson JS;Kassim BS;Sloofman L;Mattei E;Weng Z;Sieberts SK;Peters MA;Harris BT;Lipska BK;Sklar P;Roussos P;Akbarian S
通讯作者：
Akbarian S