Risk Factors for Abdominal Pain-Related Disorders of Gut-Brain Interaction in Adults and Children: A Systematic Review.
Risk Factors for Abdominal Pain-Related Disorders of Gut-Brain Interaction in Adults and Children: A Systematic Review.
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DOI：
10.1053/j.gastro.2022.06.028
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发表时间：
2022-10
期刊：
影响因子：
29.4
通讯作者：
中科院分区：
文献类型：
--
作者：
许多研究已经评估了肠易激综合征(IBS)和其他腹痛相关的肠脑相互作用障碍(AP-DGBI)的危险因素；然而，由于研究设计的多样性，这些因素的作用尚不清楚。这项系统性综述的目的是广泛评估文献，并确定儿童和成人AP-DGBI存在和持续的临床风险和保护因素。PubMed搜索确定了调查成人和儿童AP-DGBI的潜在风险和保护因素的研究。纳入标准包括与对照组的完全发表的研究；排除标准包括质量较差的研究(使用经验证的量表)。对于每个因素，总结了发现该因素是危险因素、保护因素或两者都不是的研究的比例。研究的数量、诊断标准、受试者的数量和平均研究质量评级提供了进一步的背景。只要有可能，荟萃分析就会生成合并的赔率比或平均差值。该系统综述包括348项研究。女性、胃肠炎、虐待、压力、心理障碍、躯体症状和睡眠不佳是成人和儿童发生AP-DGBI的一致危险因素。在成年人中，其他危险因素包括肥胖、吸烟和增加使用医疗资源。成人的保护性AP-DGBI因素包括社会支持和乐观；没有关于儿童保护性因素的研究。成人和儿童AP-DGBI的危险因素有多种。这些症状包括女性性行为、胃肠炎、虐待、压力、睡眠不佳、肥胖、心理障碍和躯体症状。还需要对儿童进行更多关于保护因素的研究，以及与AP-DGBI持续性相关的因素。
Many studies have assessed risk factors of irritable bowel syndrome (IBS) and other abdominal pain–related disorders of gut–brain interaction (AP-DGBI); however, the role of these factors is unclear due to heterogeneous study designs. The aim of this systematic review was to extensively evaluate the literature and determine clinical risk and protective factors for the presence and persistence of AP-DGBI in children and adults. A PubMed search identified studies investigating potential risk and protective factors for AP-DGBI in adults and children. Inclusion criteria included fully published studies with a control group; exclusion criteria included poor-quality studies (using a validated scale). For each factor, the proportion of studies that found the factor to be a risk factor, protective factor, or neither was summarized. The number of studies, diagnostic criteria, number of subjects, and average study quality rating provided further context. Whenever possible, a meta-analysis generated pooled odds ratios or mean difference. The systematic review included 348 studies. Female sex, gastroenteritis, abuse, stress, psychological disorders, somatic symptoms, and poor sleep were consistent risk factors for developing AP-DGBI in adults and children. In adults, additional risk factors included obesity, smoking, and increased use of medical resources. Protective AP-DGBI factors in adults included social support and optimism; no studies for protective factors were found for children. There are multiple risk factors for AP-DGBI in adults and children. These include female sex, gastroenteritis, abuse, stress, poor sleep, obesity, psychological disorders, and somatic symptoms. Additional studies are needed in children, on protective factors, and on factors associated with persistence of AP-DGBI.
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影响因子：
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