Left, right, or bilateral amygdala activation? How effects of smoothing and motion correction on ultra-high field, high-resolution functional magnetic resonance imaging (fMRI) data alter inferences.

Left, right, or bilateral amygdala activation? How effects of smoothing and motion correction on ultra-high field, high-resolution functional magnetic resonance imaging (fMRI) data alter inferences.
复制标题

左侧、右侧或双侧杏仁核激活?平滑和运动校正对超高场、高分辨率功能磁共振成像(FMRI)数据的影响如何改变推断。

DOI:
10.1016/j.neures.2019.01.009
复制
发表时间:
2020-01
影响因子:
2.9
通讯作者:
Robinson JL
Robinson JL
中科院分区:
医学4区
文献类型:
--
作者:
Murphy JE;Yanes JA;Kirby LAJ;Reid MA;Robinson JL

文献摘要

参考文献

被引文献

相似文献

鉴于杏仁核在生存机制中的作用,以及它对心理过程的关键贡献,它是研究最充分的大脑区域之一也就不足为奇了。了解杏仁核功能作用的常用方法之一是使用功能性磁共振成像(fMRI)。然而,功能磁共振成像往往使用的分辨率不是最佳的较小的大脑结构。此外,标准处理包括空间平滑和运动校正,这进一步降低了数据的分辨率。然而,当确定杏仁核在任务中是否活跃时,这可能是有害的。事实上,使用相同任务的研究可能会显示杏仁核(e)激活的差异。在这里,我们研究了广泛接受的预处理步骤对全脑亚毫米fMRI数据的影响,以确定与已知激活杏仁核(e)的强大任务相关的激活模式的影响。我们分析了以亚毫米平面内分辨率收集的来自30名健康个体的7T fMRI数据,并使用了具有平滑内核和运动校正选项的不同组合的场标准预处理流水线。结果杏仁核激活模式的改变取决于平滑和运动校正的组合进行,表明全脑预处理步骤有显着的影响,可以得出关于更小的,皮质下结构,如杏仁核的推论。
Given the amygdala’s role in survival mechanisms, and its pivotal contributions to psychological processes, it is no surprise that it is one of the most well-studied brain regions. One of the common methods for understanding the functional role of the amygdala is the use of functional magnetic resonance imaging (fMRI). However, fMRI tends to be acquired using resolutions that are not optimal for smaller brain structures. Furthermore, standard processing includes spatial smoothing and motion correction which further degrade the resolution of the data. Inferentially, this may be detrimental when determining if the amygdalae are active during a task. Indeed, studies using the same task may show differential amygdala(e) activation. Here, we examine the effects of well-accepted preprocessing steps on whole-brain submillimeter fMRI data to determine the impact on activation patterns associated with a robust task known to activate the amygdala(e). We analyzed 7T fMRI data from 30 healthy individuals collected at sub-millimeter in-plane resolution and used a field standard preprocessing pipeline with different combinations of smoothing kernels and motion correction options. Resultant amygdalae activation patterns were altered depending on which combination of smoothing and motion correction were performed, indicating that whole-brain preprocessing steps have a significant impact on the inferences that can be drawn about smaller, subcortical structures like the amygdala.
DOI: 10.1006/nimg.2002.1132
发表时间: 2002-10-01
期刊: NEUROIMAGE
影响因子: 5.7
作者:
Jenkinson, M;Bannister, P;Smith, S
通讯作者: Smith, S
DOI: 10.1016/s1053-8119(03)00435-x
发表时间: 2003-10-01
期刊: NEUROIMAGE
影响因子: 5.7
作者:
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者: Smith, SM
DOI: 10.1093/scan/nsw018
发表时间: 2016-06-01
影响因子: 4.2
作者:
Mattson, Whitney I.;Hyde, Luke W.;Monk, Christopher S.
通讯作者: Monk, Christopher S.
DOI: 10.2196/jmir.3243
发表时间: 2014-08-12
影响因子: 7.4
作者:
Fagundo AB;Via E;Sánchez I;Jiménez-Murcia S;Forcano L;Soriano-Mas C;Giner-Bartolomé C;Santamaría JJ;Ben-Moussa M;Konstantas D;Lam T;Lucas M;Nielsen J;Lems P;Cardoner N;Menchón JM;de la Torre R;Fernandez-Aranda F
通讯作者: Fernandez-Aranda F
DOI: 10.1016/j.jad.2016.09.026
发表时间: 2017-01-01
影响因子: 6.6
作者:
Connolly CG;Ho TC;Blom EH;LeWinn KZ;Sacchet MD;Tymofiyeva O;Simmons AN;Yang TT
通讯作者: Yang TT