Left, right, or bilateral amygdala activation? How effects of smoothing and motion correction on ultra-high field, high-resolution functional magnetic resonance imaging (fMRI) data alter inferences.
Left, right, or bilateral amygdala activation? How effects of smoothing and motion correction on ultra-high field, high-resolution functional magnetic resonance imaging (fMRI) data alter inferences.
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左侧、右侧或双侧杏仁核激活?平滑和运动校正对超高场、高分辨率功能磁共振成像(FMRI)数据的影响如何改变推断。
DOI:
10.1016/j.neures.2019.01.009
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发表时间:
2020-01
影响因子:
2.9
通讯作者:
Robinson JL
中科院分区:
文献类型:
--
作者:
Murphy JE;Yanes JA;Kirby LAJ;Reid MA;Robinson JL
Given the amygdala’s role in survival mechanisms, and its pivotal contributions to psychological processes, it is no surprise that it is one of the most well-studied brain regions. One of the common methods for understanding the functional role of the amygdala is the use of functional magnetic resonance imaging (fMRI). However, fMRI tends to be acquired using resolutions that are not optimal for smaller brain structures. Furthermore, standard processing includes spatial smoothing and motion correction which further degrade the resolution of the data. Inferentially, this may be detrimental when determining if the amygdalae are active during a task. Indeed, studies using the same task may show differential amygdala(e) activation. Here, we examine the effects of well-accepted preprocessing steps on whole-brain submillimeter fMRI data to determine the impact on activation patterns associated with a robust task known to activate the amygdala(e). We analyzed 7T fMRI data from 30 healthy individuals collected at sub-millimeter in-plane resolution and used a field standard preprocessing pipeline with different combinations of smoothing kernels and motion correction options. Resultant amygdalae activation patterns were altered depending on which combination of smoothing and motion correction were performed, indicating that whole-brain preprocessing steps have a significant impact on the inferences that can be drawn about smaller, subcortical structures like the amygdala.
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影响因子:
5.7
作者:
Jenkinson, M;Bannister, P;Smith, S
通讯作者:
Smith, S
影响因子:
5.7
作者:
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者:
Smith, SM
影响因子:
4.2
作者:
Mattson, Whitney I.;Hyde, Luke W.;Monk, Christopher S.
通讯作者:
Monk, Christopher S.
影响因子:
7.4
作者:
Fagundo AB;Via E;Sánchez I;Jiménez-Murcia S;Forcano L;Soriano-Mas C;Giner-Bartolomé C;Santamaría JJ;Ben-Moussa M;Konstantas D;Lam T;Lucas M;Nielsen J;Lems P;Cardoner N;Menchón JM;de la Torre R;Fernandez-Aranda F
通讯作者:
Fernandez-Aranda F
影响因子:
6.6
作者:
Connolly CG;Ho TC;Blom EH;LeWinn KZ;Sacchet MD;Tymofiyeva O;Simmons AN;Yang TT
通讯作者:
Yang TT