K-complexes are not preferentially evoked to combat sounds in combat-exposed Vietnam veterans with and without post-traumatic stress disorder.
K-complexes are not preferentially evoked to combat sounds in combat-exposed Vietnam veterans with and without post-traumatic stress disorder.
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DOI：
10.1016/j.ijpsycho.2011.12.009
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发表时间：
2012-03
影响因子：
3
通讯作者：
Colrain, Ian M.
中科院分区：
文献类型：
--
作者：
Franzen, Peter L.;Woodward, Steven H.;Bootzin, Richard R.;Germain, Anne;Colrain, Ian M.
本研究的主要目的是比较有和没有创伤后应激障碍（PTSD）的越战老兵对突出与非突出听觉刺激的诱发K波群反应。三类听觉刺激（标准的1000 Hz的音调，创伤相关的战斗的声音，和情感中性的环境声音），在第2阶段睡眠期间，利用一个古怪的范例，发生概率分别为60%，20%和20%。24名越战老兵，14名患有创伤后应激障碍，10名没有创伤后应激障碍，在位于加利福尼亚州门洛帕克的国家创伤后应激障碍中心的睡眠实验室进行了研究。虽然在患者中引起的K复合体总体上显着减少，但两组内由音调和战斗刺激引起的K复合体的比例没有差异。患者产生了显着更多的K-复合中性刺激比音调或战斗刺激。诱发的K波群的N550成分的检查显示患者组的潜伏期显著延长。在整个样本中，N550潜伏期较长的战斗刺激相对于音调中性刺激。N550振幅没有组或刺激类别差异。结果表明，显著的信息，定义为创伤相关的战斗声音，没有优先引发K-复合物在PTSD组或对照组，这表明K-复合物的功能，以保护睡眠比内源性处理有意义的刺激。
The primary objective was to compare the evoked K-complex response to salient versus non-salient auditory stimuli in combat-exposed Vietnam veterans with and without Post-Traumatic Stress Disorder (PTSD). Three categories of auditory stimuli (standard 1000Hz tones, trauma-related combat sounds, and affectively neutral environmental sounds) were presented during stage 2 sleep utilizing an oddball paradigm with probabilities of occurrence of 60%, 20% and 20% respectively. Twenty-four combat-exposed Vietnam veterans, 14 with PTSD and 10 without PTSD were studied in a sleep laboratory at the National Center for PTSD in Menlo Park, CA. While significantly fewer K-complexes overall were elicited in patients, there were no differences in the proportion of K-complexes elicited by tones and combat stimuli within either group. Patients produced significantly more K-complexes to neutral stimuli than to tone or combat stimuli. Examination of the N550 component of the evoked K-complex revealed significantly longer latencies in the patient group. Across the entire sample, N550 latencies were longer for combat stimuli relative to tone neutral stimuli. There were no group or stimulus category differences for N550 amplitude. The results suggest that salient information, as defined by trauma-related combat sounds, did not preferentially elicit K-complexes in either the PTSD group or the control group, suggesting that K-complexes function to protect sleep more than to endogenously process meaningful stimuli.
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睡眠唤起的三角洲频率反应显示，整个成人寿命的振幅线性下降。
影响因子：
4.2
作者：
Colrain, Ian M.;Crowley, Kate E.;Nicholas, Christian L.;Afifi, Lamia;Baker, Fiona C.;Padilla, Mayra;Turlington, Sharon R.;Trinder, John
通讯作者：
Trinder, John
影响因子：
2.3
作者：
Afifi, L;Guilleminault, C;Colrain, IM
通讯作者：
Colrain, IM
DOI：
10.1016/0013-4694(91)90021-u
发表时间：
1991-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
DAROSA, AC;KEMP, B;KAMPHUISEN, HAC
通讯作者：
KAMPHUISEN, HAC
影响因子：
4.4
作者：
Cote, KA;De Lugt, DR;Campbell, KB
通讯作者：
Campbell, KB
影响因子：
5.6
作者：
Gora, J;Colrain, IM;Trinder, J
通讯作者：
Trinder, J